Table 2 Complication related to HAIC
Study | Complication |
|---|---|
Nomami 1991 | No serious complications attributable to the adjuvant arterial chemotherapy were observed. Some patients complained of transient fever or uncomfortable feelings after the injection of doxorubicin, mitomycin C, and lipiodol |
Kim 2011 | No serious systemic adverse events (AEs) was observed |
Kumatoto 2013 | A total of 6.3% of patients experienced grade 3 decreases in white blood cell and neutrophil counts |
Nagano 2013 | Easily controlled fever was common, but no serious systemic AEs was observed |
Nitta 2013 | A total of 7.9% of patients experienced grade 3/4 neutropenia and vomiting |
Kojima 2015 | One developed grade 2 acute kidney injury and one had persistent grade 3 myelosuppression |
Feng 2017 | Paresthesia (14 of 42), neutropenia (15 of 42), thrombocytopenia (16 of 42), anemia (10 of 42), nausea or vomiting (30 of 42), diarrhea (8 of 42), and hepatic toxicity (25 of 42). All toxicities and complications were controlled |
Hsiao 2017 | Nausea, vomiting, and mild AST/ALT elevation were noted, but no serious AEs was observed |
Hamada 2020 | Not mentioned |
Hirokawa 2020 | A total of 5.4% of patients experienced grade 3 AST/ALT elevation. No grade 4 AEs was observed |
Li 2022 | A total of 82, 22, and 2 patients experienced grade 1, grade 2, and grade 3–4 AEs, respectively |