Study | Design | NOS | Group | Sample size | Tumor size, cm | Number of tumor S/M | Tumor differentiation well/moderately/poorly | Surgical margin N/P | Portal vein invasion yes/no | MVI yes/no | median OS (month) | median DFS (month) | Chemotherapy |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nomami | R | 6 | LR + HAIC | 19 | NA | NA | NA | NA | NA | NA | NA | NA | 5-FU + DO + MI |
1991 Japan | LR alone | 113 | NA | NA | NA | NA | NA | NA | NA | NA | |||
Kim | R | 7 | LR + HAIC | 31 | 4.8 ± 2.3 | 29/2 | 0/10/14 | 8/23 | 11/20 | 25/6 | NR | 10.5 | 5-FU + CI |
2011 Korea | LR alone | 62 | 4.3 ± 2.4 | 60/2 | 1/20/34 | 23/39 | 13/49 | 43/19 | NR | 7.5 | |||
Kumatoto | R | 9 | LR + HAIC | 16 | 7.61 ± 4.34 | NA | NA | NA | 16/0 | NA | 55.3 | 12.2 | 5‐FU + Interferon |
2013 Japan | LR alone | 17 | 9.48 ± 6.54 | NA | NA | NA | 12/5 | NA | 16.1 | 6.9 | |||
Nagano | R | 7 | LR + HAIC | 30 | NA | NA | NA | NA | 30/0 | NA | 36.5 | 29 | 5‐FU + Interferon |
2013 Japan | LR alone | 20 | NA | NA | NA | NA | 20/0 | NA | 8.5 | 5.5 | |||
Nitta | R | 8 | LR + HAIC | 38 | 6.66 ± 3.93 | 13/25 | 14/23/1 | 33/5 | 38/0 | NA | 55 | 13 | 5-FU + CI/5-FU + CI + MI |
2013 Japan | LR alone | 35 | 7.00 ± 4.23 | 12/23 | 22/12/1 | 32/3 | 35/0 | NA | 26 | 7 | |||
Kojima | R | 9 | LR + HAIC | 27 | 7.0 (2.8–18.0) | 10/17 | 1/12/12 | 19/8 | 27/0 | NA | 33.2 | 12.4 | 5-FU + CI + EP |
2015 Japan | LR alone | 25 | 5.0 (1.4–17.0) | 8/17 | 3/9/12 | 19/6 | 25/0 | NA | 21.5 | 6.2 | |||
Feng | R | 9 | LR + HAIC | 42 | 6.2 ± 1.5 | 24/18 | 10/12/20 | NA | 0/42 | 28/14 | 51.1 | 42.2 | 5-FU + OX + MI |
2017 China | LR alone | 43 | 5.7 ± 1.3 | 23/20 | 12/14/17 | NA | 0/43 | 25/18 | 32.8 | 22.1 | |||
Hsiao | R | 7 | LR + HAIC | 61 | 20(<= 5 cm) 41(> 5 cm) | 33/28 | 0/16/45 | 33(< 10 mm) 28 (≥ 10 mm) | 0/61 | NA | 56.4 | 50.6 | 5-FU + CI + LE + EP |
2017 China | LR alone | 160 | 81(<= 5 cm) 79(> 5 cm) | 81/79 | 0/56/104 | 121(< 10 mm) 39 (≥ 10 mm) | 0/160 | NA | 56.9 | 54.5 | |||
Hamada | R | 7 | LR + HAIC | 37 | 5.4 ± 3.6 | NA | 7/30 (well/other) | NA | 37/0 | 37/0 | NR | 22.7 | CI |
2020 Japan | LR alone | 85 | 5.7 ± 3.7 | NA | 17/68 (well/other) | NA | 52/33 | 62/23 | NR | 10.5 | |||
Hirokawa | RCT | / | LR + HAIC | 55 | 3.4 (1.0–14.5) | 41/14 | 46/9 (other/poorly) | 5 (0–32) mm | 0/55 | 14/41 | NR | 44.9 | CI + LI |
2020 Japan | LR alone | 59 | 3.1 (1.0–12) | 51/8 | 14/45 (other/poorly) | 5 (0–36) mm | 0/59 | 11/48 | NR | 35 | |||
Li | RCT | / | LR + HAIC | 157 | 5.6 (1.8–30.0) | 114/45 | 4/59/92 | NA | 0/157 | 157/0 | NR | 20.3 | FOLFOX |
2022 China | LR alone | 158 | 5.4 (1.5–16.0) | 128/30 | 2/76/80 | NA | 0/158 | 158/0 | NR | 10.0 |