Adverse events | SOX + apatinib (N = 21) | SOX (N = 29) | P value | ||
---|---|---|---|---|---|
Any grade, n (%) | Grade 3/4, n (%) | Any grade, n (%) | Grade 3/4, n (%) | ||
Neutropenia | 9 (42.9%) | 3 (14.3%) | 11 (37.9%) | 4 (13.8%) | 0.731 |
Leukopenia | 7 (33.3%) | 2 (9.5%) | 9 (31.0%) | 3 (10.3%) | 0.712 |
Thrombocytopenia | 3 (14.3%) | 1 (4.8%) | 4 (13.8%) | 2 (6.9%) | 0.673 |
Hypertension | 4 (19.0%) | 1 (4.8%) | 0 | 0 | 0.777 |
Hand-foot syndrome | 4 (19.0%) | 1 (4.8%) | 0 | 0 | 0.777 |
Oral mucositis | 5 (23.8%) | 0 | 0 | 0 | 0.915 |
Vomiting | 10 (47.6%) | 2 (9.5%) | 14 (48.3%) | 3 (10.3%) | 0.667 |
Peripheral neuropathy | 3 (14.3%) | 0 | 5 (17.2%) | 0 | 0.600 |
Fatigue | 4 (19.0%) | 1 (4.8%) | 6 (20.7%) | 1 (3.4%) | 0.600 |