A high serum creatine kinase (CK)-MB-to-total-CK ratio in patients with pancreatic cancer: a novel application of a traditional marker in predicting malignancy of pancreatic masses?

Table 1 Characteristics of patients with pancreatic cancer, benign pancreatic masses, and controls

Characteristics	PC	BPM	P₁	Controls	P₂^a	P₃^b
Characteristics	n=118	n=72	P₁	n=68	P₂^a	P₃^b
Age (years)	61 (55, 67)	50 (38,58)	<0.001	63 (54, 70)	1.000	<0.001
Sex, male	79 (66.9)	39 (54.2)	0.078	46 (67.6)	0.992	0.103
DM	38 (32.2)	11 (15.3)	0.010	6 (8.8)	<0.001	0.243
ALB (g/L)	42.50 (38.30, 45.73)	44.80 (43.20, 46.83)	0.001	44.10 (42.70, 45.78)	0.034	0.223
CK (IU/L)	55.00 (44.00, 74.00)	74.50 (59.25, 99.00)	<0.001	98.5 (74.5, 127)	<0.001	0.004
CK-MB (IU/L)	14.95 (11.80, 18.73)	13.60 (10.83, 16.05)	>0.050	15 (12, 17.53)	>0.050	>0.050
CK ratio	0.260 (0.182, 0.366)	0.173 (0.132, 0.230)	<0.001	0.148 (0.109, 0.197)	<0.001	0.134
NLR	2.707 (1.855, 3.451)	1.779 (1.450, 2.612)	<0.001	1.654 (1.121, 2.171)	<0.001	0.114
PNI	51.55 (44.54, 54.70)	54.40 (51.65, 56.79)	<0.001	53.775 (51.475, 56.05)	0.002	1.000
Ca19-9 (U/mL)	206.10 (53.68, 638.20)	13.39 (7.82, 20.94)	<0.001	-	-	-
Tumor site			0.248
Head and neck	61 (51.7)	31 (43.1)	-	-	-	-
Body and tail	57 (48.3)	41 (56.9)	-	-	-	-

Notes: ^aPC vs. control; ^bBPM vs. control
Abbreviations: PC, pancreatic cancer; BPM, benign pancreatic mass; DM, diabetes mellitus; ALB, albumin; CK, creatine kinase; CK ratio, CK-MB-to-total-CK ratio; NLR, neutrophil-to-lymphocyte ratio; PNI, prognostic nutrition index
Bold values are significant (<0.05)

ISSN: 1477-7819