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Table 1 Relationship between nSLN and clinicopathological factors

From: Risk factors of non-sentinel lymph node metastasis in breast cancer with 1–2 sentinel lymph node macrometastases underwent total mastectomy: a case-control study

Characteristic

nSLN-negative (n = 177)

nSLN-positive (n = 96)

t/z/x2

P value

Age at diagnosis (year) (mean ± SD)

51.24 ± 10.44

51.89 ± 11.93

−0.466

0.642

BMI (kg/m2) (median (p25–p75))

23.31 (21.24–25.89)

23.12 (21.40–26.43)

−0.707

0.480

TS (mm) (median (p25–p75))

20 (15–25)

25 (20–30)

−3.429

0.001

Total number of SLN

(median (p25–p75))

4 (3–5)

3 (2–4)

−2.937

0.003

Number of negative SLN (median (p25–p75) )

2.00 (1.00–4.00)

1.50 (0.25–3.00)

−3.959

0.001

Ratio of SLN macrometastases (median (p25–p75))

0.33 (0.25–0.50)

0.50 (0.33–0.92)

−4.987

0.001

NLR

(median (p25–p75))

1.99 (1.61–2.68)

2.00 (1.53–2.67)

−0.803

0.423

Histological grade

  

6.428

0.093

 I

20 (11.3)

3 (3.1)

  

 II

113 (63.8)

63 (65.6)

  

 III

34 (19.2)

21 (21.9)

  

 Unknown

10 (5.6)

9 (9.4)

  

Pathological type

  

4.164

0.041

 Invasive ductal carcinoma

172 (97.2)

88 (91.7)

  

 Others

5 (2.8)

8 (8.3)

  

LVI

  

6.893

0.009

 Negative

119 (67.2)

49 (51.0)

  

 Positive

58 (32.8)

47 (49.0)

  

ER status

  

0.092

0.761

 <10%

34 (19.2)

17 (17.7)

  

 ≥10%

143 (80.8)

79 (82.3)

  

PR status

  

0.026

0.872

 <10%

57 (32.2)

30 (31.3)

  

 ≥10%

120 (67.8)

66 (68.8)

  

Ki-67 index

  

1.660

0.436

 <14%

52 (29.4)

24 (25.0)

  

 ≥14%, ≤30%

67 (37.9)

44 (45.8)

  

 >30%

58 (32.8)

28 (29.2)

  

Her2 status

  

0.180

0.672

 Negative

135 (76.3)

71 (74.0)

  

 Positive

42 (23.7)

25 (26.0)

  

Molecular type

  

3.426

0.489

 Luminal A

65 (36.7)

27 (28.1)

  

 Luminal B-Her ()

58 (32.8)

36 (37.5)

  

 Luminal B-Her2 (+)

22 (12.4)

17 (17.7)

  

 ERBB2 (+)

15 (8.5)

6 (6.3)

  

 Basal-like

17 (9.6)

10 (10.4)

  

Tumor site

  

11.353

0.023

 Upper outer

80 (45.2)

61 (63.5)

  

 Lower outer

22 (12.4)

13 (13.7)

  

 Lower inner

15 (8.5)

3 (3.2)

  

 Upper inner

45 (25.4)

13 (13.7)

  

 Central portion

15 (8.5)

6 (6.3)

  

Multifocal lesions

  

2.513

0.113

 No

169 (95.5)

87 (90.6)

  

 Yes

8 (4.5)

9 (9.4)

  

Menstrual status

  

1.887

0.170

 Premenopausal

102 (57.6)

47 (49.0)

  

 Postmenopausal

75 (42.4)

49 (51.0)

  

Family history of malignancy

  

3.227

0.196

 None

133 (75.1)

71 (74.0)

  

 Breast or ovarian cancer

16 (9.0)

4 (4.2)

  

 Other malignant tumors

28 (15.8)

21 (21.9)