Table 2 Comparison of patient characteristics between HIPEC protocols
From: Serum procalcitonin improves diagnosis of infectious complications after CRS/HIPEC
Mitomycin C | Oxaliplatin | Cisplatin | p-value | |
|---|---|---|---|---|
Number of patients | 123 | 48 | 77 | |
HIPEC | ||||
Perfusion time (min) | 90 | 30 | 90 | |
Temperature (°C) | 42 | 43 | 42 | |
Primary tumor | 0.000 | |||
Colorectal | 44 (36%) | 25 (52%) | 7 (9%) | |
High-grade appendix | 32 (26%) | 19 (40%) | 2 (3%) | |
Low-grade appendix | 38 (31%) | 0 | ||
Mesothelioma | 0 | 0 | 14 (18%) | |
Others | 9 (7%) | 4 (8%) | 54 (70%) | |
PCI | 10 (4–21) | 8 (3–17) | 9 (4–20) | 0.17 |
Operation time (min) | 540 (445–685) | 361 (284–479) | 405 (281–546) | 0.000 |
Splenectomy | 26 (21.2%) | 9 (18.8%) | 18 (23.4%) | 0.50 |
ICU stay | 1 (1–2) | 1 (1–4) | 2 (1–5) | 0.000 |
Hospital stay | 18 (13–25) | 17 (15–31) | 16 (12–20) | 0.035 |
Infectious complications | 39 (32%) | 10 (21%) | 12 (16%) | 0.028 |
Superficial | 7/39 (18%) | 4/10 (40%) | 1/12 (8%) | 0.53 |
Deep incisional | 1/39 (3%) | 1/10 (10%) | 1/12 (8%) | 1.00 |
Organ/space | 31/39 (79%) | 5/10 (50%) | 10/12 (84%) | 0.000 |
Intestinal leak | 7/31 (26%) | 0 | ||
Urinary infection | 5/31 (16%) | 0 | 1/10 (10%) | |
Positive blood culture | 8/31(26%) | 1/5 (20%) | 2 (20%) | |
Pneumonia | 3/31 (9%) | 1/5 (20%) | 4 (40%) | |
Intraabdominal abscess | 4/31 (13%) | 2/5 (40%) | 2 (20%) | |
Infected pancreatic fistula | 1/31 (2%) | 1/5 (20%) | 1 (10%) | |
Bacterial peritonitis | 2/31 (6%) | 0 | 0 | |
Other a | 1/31 (2%) | 0 | 0 | |