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Table 3 A summary of cases attended

From: A review of 14 cases of perianal Paget’s disease: characteristics of anorectal cancer with pagetoid spread

Case

Gender

Initial treatment

Immunohistological findings

Primary

Histology*

LN mets

Mapping biopsy

1st relapse

Outcome

Age

Lymph node dissection

CK7

CK20

GCDFP15

CDX2

Maximum diameter

Depth of invasion

Location of LN

Resection status

Interval

Treatment

Follow-up time (primary)

No detectable primary lesion

 1

M

WLE

+

NA

+

Unknown

Adenocarcinoma

Negative

Done

ILN

ILND

Dead of disease

76

None

55mm

Invasive

R1

61 months

6 years

 2

M

WLE

+

+

+

Unknown

Adenocarcinoma

NA

Done

ILN

ILND

Alive with no evidence of disease

55

None

30mm

Non-invasive

R1

34 months

13 years

 3

F

RT

+

Unknown

Adenocarcinoma

NA

None

Local

Medication

Alive with 2nd relapse

78

None

NA

NA

87 months

12 years

 4

F

APR with WLE

+

+

+

Unknown

Adenocarcinoma

Negative

None

NA

NA

Alive with no evidence of disease

73

D2

74mm

MP

R0

5 years

 5

F

WLE

NA

Unknown

Muc

Positive

Done

NA

NA

Alive with no evidence of disease

63

ILND

80mm

Invasive

Inguinal

R0

2 years

 6

M

WLE

+

+

Unknown

Adenocarcinoma

Negative

None

Local

WLE

Alive with 2nd relapse

80

None

50mm

Invasive

R0

25 months

5 years

Detectable underlying anorectal carcinoma

 7

M

APR with WLE

+

NA

+

P

Muc/sig

Positive

None

ILN

ILND

Dead of disease

68

D3,LLND

110mm

AI

Lateral pelvic

R1

7 months

2 years

 8

M

Transanal LE with WLE

+

+

P

Tub1

NA

None

NA

Alive with no evidence of disease

72

None

9mm

SM1

R0

5 years

 9

F

APR with WLE

+

+

+

P

Tub1/por/sig

Negative

Done

LD/ILN

LLND

Alive with no evidence of disease

80

D2

90mm

MP

R1

13 months

ILND

2 years

 10

M

APR with WLE

+

+

NA

+

P

Adenocarcinoma

Negative

None

NA

Alive with no evidence of disease

66

D2

106mm

M

R0

3 years

 11

F

NA

+

+

+

Rb

NA

NA

NA

NA

Unknown

69

None

Unknown

3 years

 12

F

Transanal LE with WLE

+

+

+

P

Por2/tub2/muc

NA

Done

Local

WLE

Alive with no evidence of disease

84

None

52mm

M

R1

36 months

4 years

No preoperative diagnosis of pagetoid spread

 13

M

Trans anal LE*

NA

NA

NA

NA

P

Tub2/por

NA

NA

Local

WLE

Alive with 2nd relapse

74

None

10mm

SM

159 months

13 years

 14

F

Chemoterapy

NA

NA

NA

+

P

Por/sig

Positive

None

NA

Alive with

74

D3, LLND, ILND

25mm

A

Inguinal

Positive

1 year

  1. APR abdominal perineal rectal dissection, WLE wide local excision, LLND lateral lymph node dissection, ILND inguinal lymph node dissection