Case | Gender | Initial treatment | Immunohistological findings | Primary | Histology* | LN mets | Mapping biopsy | 1st relapse | Outcome | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Age | Lymph node dissection | CK7 | CK20 | GCDFP15 | CDX2 | Maximum diameter | Depth of invasion | Location of LN | Resection status | Interval | Treatment | Follow-up time (primary) | |
No detectable primary lesion | |||||||||||||
1 | M | WLE | − | + | NA | + | Unknown | Adenocarcinoma | Negative | Done | ILN | ILND | Dead of disease |
76 | None | 55mm | Invasive | R1 | 61 months | 6 years | |||||||
2 | M | WLE | + | + | − | + | Unknown | Adenocarcinoma | NA | Done | ILN | ILND | Alive with no evidence of disease |
55 | None | 30mm | Non-invasive | R1 | 34 months | 13 years | |||||||
3 | F | RT | − | + | − | − | Unknown | Adenocarcinoma | NA | None | Local | Medication | Alive with 2nd relapse |
78 | None | NA | NA | 87 months | 12 years | ||||||||
4 | F | APR with WLE | + | + | − | + | Unknown | Adenocarcinoma | Negative | None | NA | NA | Alive with no evidence of disease |
73 | D2 | 74mm | MP | R0 | 5 years | ||||||||
5 | F | WLE | − | − | NA | − | Unknown | Muc | Positive | Done | NA | NA | Alive with no evidence of disease |
63 | ILND | 80mm | Invasive | Inguinal | R0 | 2 years | |||||||
6 | M | WLE | + | + | − | − | Unknown | Adenocarcinoma | Negative | None | Local | WLE | Alive with 2nd relapse |
80 | None | 50mm | Invasive | R0 | 25 months | 5 years | |||||||
Detectable underlying anorectal carcinoma | |||||||||||||
7 | M | APR with WLE | − | + | NA | + | P | Muc/sig | Positive | None | ILN | ILND | Dead of disease |
68 | D3,LLND | 110mm | AI | Lateral pelvic | R1 | 7 months | 2 years | ||||||
8 | M | Transanal LE with WLE | − | + | − | + | P | Tub1 | NA | None | NA | Alive with no evidence of disease | |
72 | None | 9mm | SM1 | R0 | 5 years | ||||||||
9 | F | APR with WLE | + | + | − | + | P | Tub1/por/sig | Negative | Done | LD/ILN | LLND | Alive with no evidence of disease |
80 | D2 | 90mm | MP | R1 | 13 months | ILND | 2 years | ||||||
10 | M | APR with WLE | + | + | NA | + | P | Adenocarcinoma | Negative | None | NA | Alive with no evidence of disease | |
66 | D2 | 106mm | M | R0 | 3 years | ||||||||
11 | F | NA | + | + | − | + | Rb | NA | NA | NA | NA | Unknown | |
69 | None | Unknown | 3 years | ||||||||||
12 | F | Transanal LE with WLE | + | + | − | + | P | Por2/tub2/muc | NA | Done | Local | WLE | Alive with no evidence of disease |
84 | None | 52mm | M | R1 | 36 months | 4 years | |||||||
No preoperative diagnosis of pagetoid spread | |||||||||||||
13 | M | Trans anal LE* | NA | NA | NA | NA | P | Tub2/por | NA | NA | Local | WLE | Alive with 2nd relapse |
74 | None | 10mm | SM | 159 months | 13 years | ||||||||
14 | F | Chemoterapy | NA | NA | NA | + | P | Por/sig | Positive | None | NA | Alive with | |
74 | D3, LLND, ILND | 25mm | A | Inguinal | Positive | 1 year |