Table 4 Univariate and multivariate analyses of factors associated with overall survival rates

Sex male (vs. female)

1.209

0.662–2.210

0.537

Age (years)

1.043

0.980–1.111

0.188

Weight (kg)

0.977

0.953–1.001

0.063

0.993

0.930–1.061

0.845

BMI (kg/m²)

0.908

0.836–0.986

0.022

0.972

0.772–1.223

0.809

 1

-

-

-

 2

0.450

0.108–1.882

0.274

 3

0.249

0.041–1.512

0.131

Diabetes yes (vs. no)

0.720

0.304–1.704

0.455

Hypertension yes (vs. no)

0.769

0.403–1.466

0.424

Coronary heart disease yes (vs. no)

0.042

0.001–2.783

0.138

History of smoking yes (vs. no)

1.002

0.554–1.812

0.995

History of alcohol consumption yes (vs. no)

0.977

0.534–1.787

0.941

Hepatitis B virus infection yes (vs. no)

0.696

0.310–1.562

0.380

Liver cirrhosis, yes (vs. no)

0.481

0.189–1.221

0.124

Ascites, yes (vs. no)

0.598

0.082–4.372

0.613

CA-19-9 (U/ml)

1.002

1.001–1.003

0.000

1.002

1.001–1.003

0.000

AFP (U/ml)

1.004

0.999–1.010

0.105

CEA (U/ml)

1.002

0.999–1.005

0.169

Neutrophil count (10⁹/L)

1.334

1.145–1.554

0.000

1.207

0.993–1.467

0.059

Lymphocyte count (10⁹/L)

0.930

0.765–1.130

0.465

Platelet count (10⁹/L)

1.004

1.000–1.008

0.042

1.001

0.996–1.005

0.769

HGB (g/L)

0.987

0.973–1.001

0.062

0.991

0.970–1.012

0.389

ALT (U/L)

1.000

0.995–1.004

0.819

AST (U/L)

1.006

1.000–1.012

0.035

1.003

0.996–1.010

0.432

TBIL (umol/L)

1.001

0.997–1.005

0.546

ALB (g/L)

0.970

0.922–1.022

0.251

Tumor diameter (cm)

1.070

0.977–1.172

0.143

Tumor number multiple (vs. single)

1.662

0.582–4.747

0.342

 Poorly differentiated

-

-

-

 Moderately differentiated

0.417

0.213–0.816

0.011

0.344

0.159–0.744

0.007

 Well differentiated

0.502

0.200–1.259

0.142

0.840

0.317–2.548

0.926

 TNM stage >II (vs. ≤II)

3.912

2.138–7.156

0.000

2.337

0.850–6.428

0.100

 Lymphatic metastasis, yes (vs. no)

4.331

2.225–8.431

0.000

1.804

0.683–4.765

0.234

 Satellite foci yes (vs. no)

2.535

1.122–5.725

0.025

0.414

0.136–1.261

0.121

 Microscopic microvascular invasion yes (vs. no)

1.574

0.774–3.200

0.210

 Liver capsule invasion yes (vs. no)

1.929

1.020–3.646

0.043

1.244

0.464–3.337

0.664

 Microscopic perineural invasion yes (vs. no)

1.579

0.775–3.219

0.208

 Lymph node dissection yes (vs. no)

1.420

0.791–2.550

0.240

 0

 1–5

1.480

0.805–2.719

0.207

 ≥6

1.132

0.339–3.775

0.840

Operative time (min)

1.002

0.999–1.005

0.267

Surgical margin R1 (vs. R0)

0.936

0.288–3.045

0.913

LH (vs. OH)

0.789

0.380–1.642

0.527