Table 7 SNP–SNP interaction models of CYP19A1 polymorphisms in lung cancer susceptibility

SNP-SNP interaction

 rs28757157

0.5551

0.5503

10/10

0.0006

 rs28757157, rs3751592

0.5620

0.5193

4/10

0.0002

 rs28757157, rs3751592, rs3751591

0.5721

0.5428

9/10

 < 0.0001

 rs28757157, rs3751592, rs3751591, rs59429575

0.5827

0.5450

10/10

 < 0.0001

CYP19A1 gene-environment interaction

 rs28757157

0.555

0.550

10/10

0.0006

 Gender, smoke

0.581

0.581

10/10

 < 0.0001

 Gender, BMI, smoke

0.593

0.560

5/10

 < 0.0001

 rs28757157, rs3751591, gender, smoke

0.608

0.532

5/10

 < 0.0001

 rs28757157, rs3751591, gender, BMI, smoke

0.636

0.601

9/10

 < 0.0001

 rs28757157, rs3751592, rs3751591, gender, BMI, smoke

0.658

0.560

4/10

 < 0.0001

 rs28757157, rs3751592, rs3751591, rs59429575, gender, BMI, smoke

0.685

0.558

8/10

 < 0.0001