Table 4 Stratification analyses by demographic characteristics for the association between CYP19A1 polymorphisms and the risk of lung cancer

Age, years

 > 60

 ≤ 60

rs28757157

Genotype

C/C

172 (65.2%)

156 (60.5%)

1

0.490

141 (69.8%)

120 (57.1%)

1

0.018

T/C

84 (31.8%)

94 (36.4%)

1.25 (0.86–1.82)

60 (29.7%)

89 (42.4%)

1.83 (1.20–2.79)

T/T

8 (3%)

8 (3.1%)

1.11 (0.39–3.10)

1 (0.5%)

1 (0.5%)

1.37 (0.08–22.91)

Dominant

C/C

172 (65.2%)

156 (60.5%)

1

0.240

141 (69.8%)

120 (57.1%)

1

0.005

T/C-T/T

92 (34.9%)

102 (39.5%)

1.24 (0.86–1.79)

61 (30.2%)

90 (42.9%)

1.82 (1.20–2.77)

Recessive

C/C-T/C

256 (97%)

250 (96.9%)

1

0.970

201 (99.5%)

209 (99.5%)

1

0.960

T/T

8 (3%)

8 (3.1%)

1.02 (0.37–2.83)

1 (0.5%)

1 (0.5%)

1.08 (0.07–17.89)

Log-additive

–-

–-

–-

1.18 (0.86–1.63)

0.300

–-

–-

1.78 (1.18–2.68)

0.006

rs3751592

Genotype

T/T

198 (74.7%)

210 (77.5%)

1

0.068

170 (84.2%)

164 (75.2%)

1

0.032

C/T

63 (23.8%)

51 (18.8%)

0.73 (0.47–1.12)

30 (14.8%)

49 (22.5%)

1.87 (1.12–3.15)

C/C

4 (1.5%)

10 (3.7%)

2.65 (0.80–8.73)

2 (1%)

5 (2.3%)

2.66 (0.50–14.21)

Dominant

T/T

198 (74.7%)

210 (77.5%)

1

0.390

170 (84.2%)

164 (75.2%)

1

0.010

C/T-C/C

67 (25.3%)

61 (22.5%)

0.84 (0.56–1.26)

32 (15.8%)

54 (24.8%)

1.93 (1.16–3.19)

Recessive

T/T-C/T

261 (98.5%)

261 (96.3%)

1

0.071

200 (99%)

213 (97.7%)

1

0.290

C/C

4 (1.5%)

10 (3.7%)

2.83 (0.86–9.30)

2 (1%)

5 (2.3%)

2.35 (0.44–12.51)

Log-additive

–-

–-

–-

0.97 (0.69–1.38)

0.870

–-

–-

1.81 (1.15–2.86)

0.009

rs59429575

Genotype

C/C

190 (72%)

196 (72.3%)

1

0.260

158 (78.2%)

149 (68.3%)

1

0.047

T/C

68 (25.8%)

62 (22.9%)

0.86 (0.57–1.30)

38 (18.8%)

58 (26.6%)

1.71 (1.06–2.76)

T/T

6 (2.3%)

13 (4.8%)

2.00 (0.73–5.50)

6 (3%)

11 (5%)

1.99 (0.71–5.64)

Dominant

C/C

190 (72%)

196 (72.3%)

1

0.820

158 (78.2%)

149 (68.3%)

1

0.014

T/C-T/T

74 (28%)

75 (27.7%)

0.96 (0.65–1.41)

44 (21.8%)

69 (31.6%)

1.75 (1.11–2.75)

Recessive

C/C-T/C

258 (97.7%)

258 (95.2%)

1

0.140

196 (97%)

207 (95%)

1

0.280

T/T

6 (2.3%)

13 (4.8%)

2.08 (0.76–5.67)

6 (3%)

11 (5%)

1.75 (0.62–4.91)

Log-additive

–-

–-

–-

1.05 (0.76–1.46)

0.760

–-

–-

1.57 (1.08–2.29)

0.016

Gender

Males

Females

rs28757157

Genotype

C/C

213 (65.5%)

192 (60.2%)

1

0.280

100 (70.9%)

84 (56.4%)

1

0.100

T/C

104 (32%)

120 (37.6%)

1.30 (0.93–1.81)

40 (28.4%)

63 (42.3%)

1.75 (1.03–2.97)

T/T

8 (2.5%)

7 (2.2%)

0.91 (0.32–2.60)

1 (0.7%)

2 (1.3%)

1.91 (0.17–21.86)

Dominant

C/C

213 (65.5%)

192 (60.2%)

1

0.150

100 (70.9%)

84 (56.4%)

1

0.033

T/C-T/T

112 (34.5%)

127 (39.8%)

1.27 (0.92–1.76)

41 (29.1%)

65 (43.6%)

1.76 (1.04–2.96)

Recessive

C/C-T/C

317 (97.5%)

312 (97.8%)

1

0.720

140 (99.3%)

147 (98.7%)

1

0.710

T/T

8 (2.5%)

7 (2.2%)

0.83 (0.29–2.35)

1 (0.7%)

2 (1.3%)

1.56 (0.14–17.69)

Log-additive

–-

–-

–-

1.20 (0.89–1.61)

0.230

–-

–-

1.70 (1.03–2.80)

0.036

Smoking

Yes

No

rs28757157

Genotype

C/C

164 (69.8%)

140 (59.8%)

1

0.095

149 (64.5%)

136 (58.1%)

1

0.330

T/C

67 (28.5%)

89 (38%)

1.56 (1.04–2.34)

77 (33.3%)

94 (40.2%)

1.35 (0.91–2.00)

T/T

4 (1.7%)

5 (2.1%)

1.37 (0.35–5.28)

5 (2.2%)

4 (1.7%)

0.97 (0.24–3.90)

Dominant

C/C

164 (69.8%)

140 (59.8%)

1

0.031

149 (64.5%)

136 (58.1%)

1

0.150

T/C-T/T

71 (30.2%)

94 (40.2%)

1.55 (1.04–2.30)

82 (35.5%)

98 (41.9%)

1.33 (0.90–1.96)

Recessive

C/C-T/C

231 (98.3%)

229 (97.9%)

1

0.830

226 (97.8%)

230 (98.3%)

1

0.840

T/T

4 (1.7%)

5 (2.1%)

1.16 (0.30–4.42)

5 (2.2%)

4 (1.7%)

0.87 (0.22–3.45)

Log-additive

–-

–-

–-

1.46 (1.01–2.10)

0.042

–-

–-

1.26 (0.88–1.80)

0.210

Drinking

Yes

No

rs28757157

Genotype

C/C

110 (73.8%)

82 (60.7%)

1

0.033

203 (64%)

194 (58.3%)

1

0.290

T/C

38 (25.5%)

52 (38.5%)

2.03 (1.18–3.50)

106 (33.4%)

131 (39.3%)

1.29 (0.94–1.79)

T/T

1 (0.7%)

1 (0.7%)

2.46 (0.11–57.00)

8 (2.5%)

8 (2.4%)

1.11 (0.41–3.06)

Dominant

C/C

110 (73.8%)

82 (60.7%)

1

0.009

203 (64%)

194 (58.3%)

1

0.120

T/C-T/T

39 (26.2%)

53 (39.3%)

2.04 (1.18–3.51)

114 (36%)

139 (41.7%)

1.28 (0.93–1.76)

Recessive

C/C-T/C

148 (99.3%)

134 (99.3%)

1

0.700

309 (97.5%)

325 (97.6%)

1

0.980

T/T

1 (0.7%)

1 (0.7%)

1.85 (0.08–40.76)

8 (2.5%)

8 (2.4%)

1.01 (0.37–2.76)

Log-additive

–-

–-

–-

1.99 (1.17–3.36)

0.010

–-

–-

1.23 (0.92–1.63)

0.160

rs3751592

Genotype

T/T

121 (80.7%)

108 (75%)

1

0.330

247 (77.9%)

266 (77.1%)

1

0.064

C/T

27 (18%)

35 (24.3%)

1.52 (0.83–2.79)

66 (20.8%)

65 (18.8%)

0.89 (0.60–1.31)

C/C

2 (1.3%)

1 (0.7%)

0.52 (0.04–6.46)

4 (1.3%)

14 (4.1%)

3.23 (1.04–9.97)

Dominant

T/T

121 (80.7%)

108 (75%)

1

0.220

247 (77.9%)

266 (77.1%)

1

0.910

C/T-C/C

29 (19.3%)

36 (25%)

1.45 (0.80–2.62)

70 (22.1%)

79 (22.9%)

1.02 (0.71–1.48)

Recessive

T/T-C/T

148 (98.7%)

143 (99.3%)

1

0.550

313 (98.7%)

331 (95.9%)

1

0.023

C/C

2 (1.3%)

1 (0.7%)

0.47 (0.04–5.92)

4 (1.3%)

14 (4.1%)

3.31 (1.07–10.19)

Log-additive

–-

–-

–-

1.33 (0.77–2.31)

0.310

–-

–-

1.14 (0.83–1.56)

0.410

rs59429575

Genotype

C/C

117 (78%)

95 (66%)

1

0.130

231 (73.1%)

250 (72.5%)

1

0.190

T/C

30 (20%)

44 (30.6%)

1.71 (0.97–3.02)

76 (24.1%)

76 (22%)

0.90 (0.62–1.30)

T/T

3 (2%)

5 (3.5%)

2.18 (0.46–10.25)

9 (2.8%)

19 (5.5%)

1.95 (0.86–4.41)

Dominant

C/C

117 (78%)

95 (66%)

1

0.044

231 (73.1%)

250 (72.5%)

1

0.960

T/C-T/T

33 (22%)

49 (34%)

1.75 (1.01–3.03)

85 (26.9%)

95 (27.5%)

1.01 (0.71–1.42)

Recessive

C/C-T/C

147 (98%)

139 (96.5%)

1

0.420

307 (97.2%)

326 (94.5%)

1

0.084

T/T

3 (2%)

5 (3.5%)

1.87 (0.40–8.73)

9 (2.8%)

19 (5.5%)

2.00 (0.89–4.51)

Log-additive

–-

–-

–-

1.63 (1.01–2.64)

0.044

–-

–-

1.10 (0.83–1.46)

0.500