Table 6 Univariate and multivariate analyses of clinicopathological features and DFS
From: Prognostic value of elastic lamina staining in patients with stage III colon cancer
Feature | Univariate | Multivariate | ||
|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | |
Age (years) | ||||
≤ 60 | 1 | 0.439 | – | – |
> 60 | 1.313 (0.659–2.614) | |||
Sex | ||||
Male | 1 | 0.96 | – | – |
Female | 1.017 (0.514–2.016) | |||
ELI detection | ||||
T3ELI (−) | 1 | 0.001 | 1 | < 0.001 |
T3ELI (+) | 8.284 (2.177–31.521) | 8.444 (1.736–41.067) | 0.008 | |
T3EL (−) | 0.789 (0.157–3.963) | 0.891 (0.158–5.026) | 0.891 | |
T4a | 2.505 (0.677–9.263) | 2.734 (0.625–11.958) | 0.182 | |
T4b | 5.383 (1.367–21.194) | 57.727 (5.547–600.754) | 0.001 | |
Tumor location | ||||
Right-sided | 1 | 0.802 | - | - |
Left-sided | 1.094 (0.543–2.202) | |||
N stage | ||||
N1 | 1 | <0.001 | 1 | < 0.001 |
N2 | 5.605 (2.786–11.273) | 10.629 (3.858–29.286) | ||
Clinical stage | ||||
IIIA | 1 | 0.017 | – | – |
IIIB | 0.862 (0.115–6.443) | 1 | 0.008 | |
IIIC | 2.463 (0.320–18.960) | 0.136 (0.31–0.589) | ||
Pathology type | ||||
Adenocarcinoma | 1 | 0.033 | 1 | 0.426 |
Mucinous adenocarcinoma | 2.112 (1.063–4.197) | 1.421 (0.599–3.372) | ||
Tumor grade | ||||
Low | 1 | 0.172 | – | – |
High | 1.750 (0.784–3.903) | |||
Lymphovascular invasion | ||||
Absent | 1 | 0.004 | 1 | 0.25 |
Present | 3.248 (1.457–7.241) | 1.827 (0.654–5.104) | ||
PNI | ||||
Absent | 1 | 0.003 | 1 | 0.003 |
Present | 4.980 (1.173–14.312) | 8.393 (2.094–33.637) | ||
Adjuvant chemotherapy | ||||
Yes | 1 | 0.488 | – | – |
No | 1.660 (0.397–6.950) | |||