Variable | Recurrence-free survival | Overall survival | ||||||
---|---|---|---|---|---|---|---|---|
Univariate analysis | P | Multivariate analysis | P | Univariate analysis | P | Multivariate analysis | P | |
Sex (female) | 0.861 (0.666–1.113) | 0.253 | 0.758 (0.540–1.065) | 0.110 | ||||
Age (>60 years) | 0.876 (0.695–1.105) | 0.263 | 0.976 (0.730–1.304) | 0.868 | ||||
Tumor size (>5 cm) | 1.822 (1.483–2.238) | <0.001 | 1.303 (1.038–1.635) | 0.022 | 2.537 (1.902–3.385) | <0.001 | 1.409 (1.027–1.934) | 0.034 |
Number of tumors (multiple) | 1.491 (1.236–1.797) | <0.001 | 1.421 (1.175–1.718) | <0.001 | 1.532 (1.215–1.932) | <0.001 | 1.509 (1.192–1.923) | 0.001 |
Tumor capsule (incomplete) | 1.556 (1.267–1.910) | <0.001 | 1.292 (1.044–1.599) | 0.019 | 1.927 (1.510–2.459) | <0.001 | 1.518 (1.174–1.961) | 0.001 |
MVI (positive) | 1.622 (1.349–1.950) | <0.001 | 1.333 (1.095–1.623) | 0.004 | 2.173 (1.701–2.774) | <0.001 | 1.589 (1.222–2.066) | 0.001 |
BCLC stage (C) | 2.209 (1.840–2.651) | <0.001 | 1.680 (1.309–2.155) | <0.001 | 3.452 (2.755–4.326) | <0.001 | 2.239 (1.651–3.036) | <0.001 |
Edmonson grade (III–IV) | 1.841 (1.467–2.311) | <0.001 | 0.954 (0.720–1.264) | 0.741 | 2.727 (2.100–3.540) | <0.001 | 1.003 (0.727–1.384) | 0.985 |
HbsAg (positive) | 1.217 (0.928–1.594) | 0.155 | 0.933 (0.675–1.287) | 0.671 | ||||
Liver cirrhosis (yes) | 1.066 (0.890–1.277) | 0.486 | 1.009 (0.802–1.268) | 0.942 | ||||
Child–Pugh score (B) | 1.256 (0.708–2.227) | 0.436 | 1.893 (1.037–3.456) | 0.038 | 1.174 (0.624–2.208) | 0.618 | ||
Serum albumin (>35 g/L) | 0.850 (0.649–1.112) | 0.236 | 0.598 (0.440–0.812) | 0.001 | 0.841 (0.606–1.168) | 0.301 | ||
ALT (>40 U/L) | 1.266 (1.055–1.519) | 0.011 | 0.977 (0.785–1.216) | 0.837 | 1.360 (1.084–1.707) | 0.008 | 0.963 (0.740–1.259) | 0.781 |
AST (>40 U/L) | 1.595 (1.334–1.906) | <0.001 | 1.233 (0.990–1.537) | 0.061 | 2.019 (1.610–2.532) | <0.001 | 1.405 (1.075–1.838) | 0.013 |
TBil (>17.1 μmol/mL) | 0.889 (0.709–1.114) | 0.306 | 0.965 (0.728–1.280) | 0.804 | ||||
AFP (>400 ng/mL) | 1.267 (1.061–1.514) | 0.009 | 1.051 (0.850–1.300) | 0.644 | 1.558 (1.245–1.951) | <0.001 | 1.308 (0.995–1.720) | 0.054 |
CA19-9 (>37 U/mL) | 1.463 (1.193–1.794) | <0.001 | 1.393 (1.038–1.870) | 0.027 | 1.665 (1.301–2.132) | <0.001 | 1.717 (1.188–2.483) | 0.004 |
Tumor marker type (double positive) | 1.608 (1.229–2.104) | 0.001 | 1.027 (0.683–1.546) | 0.895 | 1.875 (1.362–2.581) | <0.001 | 1.259 (0.763–2.791) | 0.366 |