Fig. 3

Comparison of the mean distribution (dark gray bars) and total scores (light gray bars) (Y-axis) divided by the different tumor groups (N0T vs. N1T) and the metastatic lymph nodes (N1N) (X-axis). Col1 (a) is significantly higher in the non-metastatic tumors (N0T) compared with the metastatic ones (N1T). Col4 (b) is significantly higher in the non-metastatic tumors (N0T) compared with the metastatic ones (N1T) and even with the metastatic lymph nodes (N1N). *p <0.05, ***p <0.001