Fig. 4

Sensitivity analyses of time from baseline to first deterioration in the Quality of Life Questionnaire Core 30 items on quality of life (A), physical function (B), pain (C), and role function (D). Sensitivity analyses of mean change from baseline to follow-up between groups for the Quality of Life Questionnaire Core 30 items (E), EQ-5D VAS (F), and EQ-5D utility index (G). Sensitivity analyses of difference in mean change from baseline to follow-up within groups: PD-1/PD-L1 inhibitors (H) and controls (I)