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Table 1 Regulators of mitochondrial fission or fusion in breast cancer cells

From: Roles of mitochondrial fusion and fission in breast cancer progression: a systematic review

Regulators

Cell line

Fission/fusion

Roles

References

Hypoxia

MDA-MB-231

Fission↑

Migration↑

[27]

GBP2

MDA-MB-231 and MDA-MB-436

Fission↓

Migration↓ and invasion↓

[32]

MARCH5

MDA-MB-231 and MDA-MB-468

Fission↑

Migration↑and metastasis↑

[33]

PISD

SUM159 and MDA-MB-231-PISD

Fission↑

Migration↑, OXPHOS↑

[34]

BRCA1

MDA-MB-231

Fusion↓

Migration↓, proliferation↓, and metastasis↓

[35]

RACGAP1/LncRNA RACGAP1

MCF7 and MDA-MB-231

Fission↑, Fusion↓

Migration↑, glycolysis↑, and metastasis↑

[6]

CaMKII

MDA-MB-231

Fission↑

Apoptosis↑ and ROS↑

[36]

MiR-195

MCF-7 and MDA-MB-231

Fission↑, Fusion↓

Apoptosis↑

[37]

Mdivi-1

MCF-7 and MDA-MB-231

Fission↓

Apoptosis↓, OXPHOS↓, ATP↓

[38, 39]

MiDs

MCF7

Fission↑ and Fusion↓

Proliferation↑and apoptosis↓

[40]

MiRNA 148/152

MDA-MB-231

Fission↑

Proliferation↑

[41]

MTFR2

Hs578T, MDA-MB-231, and MCF-7

Fission↑

Proliferation↑, invasion↑ and glycolysis↑

[42]

IR-783

MDA-MB-231 and MCF-7

Fission↑

Proliferation↓, migration↓, and ATP↓

[43]

PKM2

MCF-7

Fusion↑

mtDNA↑and ATP↓

[30]

Polyphyllin I

MCF-7 and MDA-MB-231

Fission↑

Apoptosis↑, cytochrome c↑, and mitophagy↑

[44]

Silibinin

MDA-MB-231

Fusion↑

Proliferation↓, migration↓, and invasion↓

[38]

Luteolin

4T1 and MDA-MB-231

Fission↓

Apoptosis↑ and metastasis↓

[45]

Cepharanthin

MDA-MB-231 and BT549

Fission↑

Apoptosis↑and autophagy↓

[46]