From: Roles of mitochondrial fusion and fission in breast cancer progression: a systematic review
Regulators | Cell line | Fission/fusion | Roles | References |
---|---|---|---|---|
Hypoxia | MDA-MB-231 | Fission↑ | Migration↑ | [27] |
GBP2 | MDA-MB-231 and MDA-MB-436 | Fission↓ | Migration↓ and invasion↓ | [32] |
MARCH5 | MDA-MB-231 and MDA-MB-468 | Fission↑ | Migration↑and metastasis↑ | [33] |
PISD | SUM159 and MDA-MB-231-PISD | Fission↑ | Migration↑, OXPHOS↑ | [34] |
BRCA1 | MDA-MB-231 | Fusion↓ | Migration↓, proliferation↓, and metastasis↓ | [35] |
RACGAP1/LncRNA RACGAP1 | MCF7 and MDA-MB-231 | Fission↑, Fusion↓ | Migration↑, glycolysis↑, and metastasis↑ | [6] |
CaMKII | MDA-MB-231 | Fission↑ | Apoptosis↑ and ROS↑ | [36] |
MiR-195 | MCF-7 and MDA-MB-231 | Fission↑, Fusion↓ | Apoptosis↑ | [37] |
Mdivi-1 | MCF-7 and MDA-MB-231 | Fission↓ | Apoptosis↓, OXPHOS↓, ATP↓ | |
MiDs | MCF7 | Fission↑ and Fusion↓ | Proliferation↑and apoptosis↓ | [40] |
MiRNA 148/152 | MDA-MB-231 | Fission↑ | Proliferation↑ | [41] |
MTFR2 | Hs578T, MDA-MB-231, and MCF-7 | Fission↑ | Proliferation↑, invasion↑ and glycolysis↑ | [42] |
IR-783 | MDA-MB-231 and MCF-7 | Fission↑ | Proliferation↓, migration↓, and ATP↓ | [43] |
PKM2 | MCF-7 | Fusion↑ | mtDNA↑and ATP↓ | [30] |
Polyphyllin I | MCF-7 and MDA-MB-231 | Fission↑ | Apoptosis↑, cytochrome c↑, and mitophagy↑ | [44] |
Silibinin | MDA-MB-231 | Fusion↑ | Proliferation↓, migration↓, and invasion↓ | [38] |
Luteolin | 4T1 and MDA-MB-231 | Fission↓ | Apoptosis↑ and metastasis↓ | [45] |
Cepharanthin | MDA-MB-231 and BT549 | Fission↑ | Apoptosis↑and autophagy↓ | [46] |