Comparison of open, laparoscopic, and robotic left colectomy for radical treatment of colon cancer: a retrospective analysis in a consecutive series of 211 patients

Huang, Zhixiang; Li, Taiyuan; Zhang, Genghua; Zhou, Zhen; Shi, Haoran; Tang, Cheng; Yang, Lingling; Lei, Xiong

doi:10.1186/s12957-022-02796-8

Table 4 Prognostic factors of a 3-year survival and local recurrence by univariate analysis (overall cohort)

From: Comparison of open, laparoscopic, and robotic left colectomy for radical treatment of colon cancer: a retrospective analysis in a consecutive series of 211 patients

Variables	N=211	Overall survival (%)	P*	Disease-free survival (%)	P*	Cumulative local recurrence (%)	P*
Age (years)			0.707		0.809		0.410
≤65	132	88.1		79.9		7.4
> 65	79	86.0		80.2		4.4
Sex			0.090		0.898		0.312
Male	124	90.6		79.9		7.8
Female	87	82.5		80.4		3.9
BMI (kg/m²)			0.364		0.255		0.822
≤25	169	86.2		78.4		6.6
>25	42	92.1		86.9		5.4
ASA score			0.385		0.144		0.373
1	1	100.0		100.0		0.0
2	85	83.9		75.8		9.7
3	125	89.5		85.5		4.3
CEA (ng/ml)			0.056		0.001		0.010
≤6.5	164	89.7		84.7		4.0
> 6.5	47	78.6		63.5		15.5
CA199 (ng/ml)			<0.001		0.015		0.124
≤27	182	90.7		82.4		5.4
> 27	29	64.5		63.0		13.5
Surgical approach			0.671		0.776		0.797
Open	49	86.9		77.7		4.8
Laparoscopy	92	85.6		79.3		7.5
Robot	70	89.9		82.7		6.0
Previous abdominal surgery			0.528		0.307		0.285
Yes	45	90.2		85.5		9.6
No	166	86.6		78.6		5.4
Smoking and drinking history			0.433		0.222		0.155
Yes	66	90.1		74.5		4.6
No	145	86.1		82.6		10.1
Family history of CRC			0.285		0.637		0.233
Yes	21	95.0		85.2		0.0
No	190	86.4		79.5		7.1
With comorbidities			0.264		0.906		0.775
Yes	80	83.4		80.0		5.6
No	131	89.7		80.1		6.8
Postoperative adjuvant chemotherapy			<0.001		<0.001		0.220
Yes	47	70.6		85.0		10.2
No	164	92.1		62.9		5.4
Perioperative morbidity			0.963		0.758		0.740
Yes	45	87.8		77.8		5.4
No	166	87.2		80.6		6.6
Tumor location			0.821		0.542		0.511
TC&SF	50	89.2		85.6		4.4
UDC	74	85.6		76.8		4.8
LDC	87	87.7		79.6		8.7
With adenomatous polyps			0.009		0.067		0.137
Yes	56	98.0		88.6		1.8
No	155	83.6		77.0		8.1
Neoplasm diameter (cm)			0.395		0.816		0.089
≤5	136	85.8		80.7		4.2
>5	75	89.9		79.0		10.2
Tumor differentiation			0.022		0.002		0.089
Well	21	100.0		89.7		0.0
Moderate	159	88.5		83.4		5.5
Poor	20	74.4		59.2		13.8
Mucinous	11	70.0		50.5		22.2
pTNM stage			<0.001		<0.001		0.030
I	34	96.6		90.1		0.0
II	91	95.3		89.5		3.6
III	86	75.9		66.4		11.9
pT stage			0.067		0.148		0.434
T1	22	100.0		95.0		0.0
T2	13	100.0		91.7		0.0
T3	21	95.2		85.4		5.0
T4a	155	83.5		76.4		7.9
pN stage			<0.001		<0.001		0.007
N0	125	95.7		89.6		2.7
N1	58	87.5		74.9		9.1
N2	28	52.0		48.9		19.4
Number of lymph nodes detected			0.395		0.856		0.306
≤15	137	85.8		79.8		5.0
>15	74	89.9		80.4		8.8
With lymphovascular invasion			<0.001		0.001		0.059
Yes	35	69.9		59.8		14.8
No	176	90.8		83.9		4.9
With extranodal tumor deposits			0.004		<0.001		0.331
Yes	33	72.5		57.3		10.9
No	178	90.3		84.5		5.6
With perineural invasion			0.001		<0.001		<0.001
Yes	75	77.1		65.9		15.9
No	136	92.8		87.7		1.6

Abbreviation: BMI Body mass index, ASA American Society of Anesthesiology, CRC Colorectal cancer, TC The distal 1/3 of the transverse colon, SF Splenic flexure, UDC Upper segment of descending colon, LDC Lower segment of the descending colon, pTNM Pathological tumor-node-metastasis
*The 3-year overall and disease-free survival rates and cumulative local recurrence were calculated by using the Kaplan–Meier method

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ISSN: 1477-7819

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