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Table 3 Multiple regression analysis to assess the independent effect in CSS and OS and stratified effect analysis in different N stages

From: Prognostic value of lymph node density on cancer staging system for gastric cancer without distal metastasis: a population-based analysis of SEER database

LND

Non-adjusted

Adjust I

Adjust II

 

CSS, HR (95%CI) P value

OS, HR (95%CI) P value

CSS, HR (95%CI) P value

OS, HR (95%CI) P value

CSS, HR (95%CI) P value

OS, HR (95%CI) P value

Total (n = 4821)

 LND1(< 0.1)

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

 LND2(> = 0.1, < 0.4)

3.98 (3.45, 4.60) < 0.001

2.88 (2.59, 3.20) < 0.001

3.97 (3.44, 4.58) < 0.001

2.84 (2.56, 3.16) < 0.001

2.43 (2.09, 2.84) <0.001

2.04 (1.81, 2.29) < 0.001

 LND3(> = 0.4)

8.57 (7.48, 9.82) < 0.001

5.54 (4.99, 6.15) < 0.001

8.62 (7.52, 9.87) < 0.001

5.58 (5.03, 6.19) < 0.001

4.69 (4.02, 5.48) < 0.001

3.61 (3.20, 4.07) < 0.001

Subgroup analysis

N1 (n = 913)

 LND1(< 0.1)

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

 LND2(> = 0.1, <0.4)

2.23 (1.72, 2.88) < 0.001

2.21 (1.81, 2.69) <0.001

2.17 (1.67, 2.81) < 0.001

2.04 (1.67, 2.50) < 0.001

1.97 (1.51, 2.57) < 0.001

1.86 (1.52, 2.29) < 0.001

 LND3(> = 0.4)

3.59 (2.58, 4.98) < 0.001

3.18 (2.44, 4.14) < 0.001

3.39 (2.43, 4.72) < 0.001

2.88 (2.21, 3.76) < 0.001

3.12 (2.21, 4.39) < 0.001

2.65 (2.01, 3.49) < 0.001

N2 (n = 642)

 LND1(< 0.1)

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

 LND2(>= 0.1, < 0.4)

2.17 (1.25, 3.75) 0.005

2.46 (1.54, 3.92) 0.002

2.15 (1.24, 3.73) 0.006

2.44 (1.53, 3.90) 0.002

2.07 (1.19, 3.60) 0.010

2.34 (1.46, 3.76) 0.001

 LND3(> = 0.4)

4.77 (2.72, 8.38) < 0.001

5.07 (3.13, 8.21) < 0.001

4.72 (2.68, 8.30) < 0.001

4.88 (3.01, 7.92) < 0.001

4.71 (2.63, 8.46) < 0.001

4.87 (2.96, 8.01) < 0.001

N3 (n = 659)

 LND < 0.4

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

 LND > = 0.4

2.51 (1.87, 3.38) < 0.001

1.86 (1.50, 2.31) < 0.001

2.07 (1.60, 2.70) < 0.001

1.92 (1.54, 2.39) < 0.001

1.94 (1.49, 2.53) < 0.001

1.80 (1.44, 2.25) < 0.001

  1. Non-adjusted model did not adjust covariant
  2. Adjusted I model minimally adjusted for sex, age, and race
  3. Adjusted II model fully adjusted for sex, age, race, marital status at diagnosis, insurance, AJCC Stage Group 7th (2010-2015), AJCC T 7th (2010-2015), and grade
  4. Abbreviations: LND lymph node density, CSS cancer-specific survival, OS overall survival, HR hazard ratio, CI confidence Interval
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World Journal of Surgical Oncology

ISSN: 1477-7819

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