Table 2 Association between clinical variables and gastric cancer-specific survival or overall survival
Variables | CSS, HR (95%CI) P value | OS, HR (95%CI) P value |
|---|---|---|
Age at diagnosis (years) | 1.01 (1.01, 1.01) < 0.001 | 1.03 (1.02, 1.03) < 0.001 |
Sex | ||
Male | Ref. | Ref. |
Female | 0.96 (0.86, 1.08) 0.536 | 0.92 (0.84, 1.00) 0.061 |
Year of diagnosis | ||
2010 | Ref. | Ref. |
2011 | 1.13 (0.95, 1.35) 0.151 | 0.99 (0.87, 1.13) 0.866 |
2012 | 0.90 (0.75, 1.08) 0.272 | 0.90 (0.78, 1.03) 0.121 |
2013 | 0.98 (0.81, 1.18) 0.841 | 0.95 (0.83, 1.10) 0.516 |
2014 | 0.91 (0.74, 1.11) 0.336 | 0.89 (0.77, 1.04) 0.141 |
2015 | 0.91 (0.72, 1.13) 0.384 | 0.79 (0.66, 0.94) 0.009 |
Race | ||
White | Ref. | Ref. |
Asian or Pacific islander | 0.79 (0.68, 0.92) 0.002 | 0.71 (0.63, 0.80) <0.001 |
Black | 1.03 (0.87, 1.21) 0.740 | 1.02 (0.90, 1.16) 0.757 |
Other | 0.76 (0.42, 1.38) 0.372 | 0.65 (0.40, 1.05) 0.079 |
Marital status at diagnosis | ||
Married | Ref. | Ref. |
Widowed | 1.40 (1.20, 1.63) < 0.001 | 1.52 (1.36, 1.71) < 0.001 |
Single | 1.32 (1.12, 1.56) 0.001 | 1.26 (1.11, 1.43) 0.001 |
Other | 0.99 (0.83, 1.18) 0.902 | 1.08 (0.95, 1.24) 0.242 |
Insurance | ||
Insured | Ref. | Ref. |
Uninsured or unknown | 1.21 (1.08, 1.35) 0.001 | 1.13 (1.03, 1.23) 0.007 |
Primary site | ||
Upper | Ref. | Ref. |
Middle | 0.96 (0.82, 1.11) 0.553 | 0.98 (0.87, 1.10) 0.699 |
Lower | 1.03 (0.90, 1.19) 0.646 | 1.10 (0.98, 1.22) 0.093 |
Overlapping lesion | 1.48 (1.21, 1.82) 0.001 | 1.36 (1.16, 1.60) 0.001 |
AJCC stage group, 7th (2010-2015) | ||
Stage I | Ref. | Ref. |
Stage II | 3.40 (2.79, 4.13) < 0.001 | 2.12 (1.87, 2.40) < 0.001 |
Stage III | 9.75 (8.18, 11.62) < 0.001 | 4.80 (4.30, 5.35) < 0.001 |
AJCC T, 7th (2010-2015) | ||
T1 | Ref. | Ref. |
T2 | 1.99 (1.56, 2.55) < 0.001 | 1.44 (1.23, 1.69) < 0.001 |
T3 | 4.76 (3.96, 5.73) < 0.001 | 2.81 (2.50, 3.16) < 0.001 |
T4 | 10.10 (8.36, 12.20) < 0.001 | 5.16 (4.55, 5.85) < 0.001 |
AJCC N, 7th (2010-2015) | ||
N0 | Ref. | Ref. |
N1 | 3.35 (2.85, 3.94) < 0.001 | 2.27 (2.02, 2.55) < 0.001 |
N2 | 5.02 (4.24, 5.93) < 0.001 | 3.13 (2.77, 3.55) < 0.001 |
N3 | 9.14 (7.84, 10.67) < 0.00 | 5.32 (4.75, 5.96) < 0.001 |
Grade | ||
Well differentiated | Ref. | Ref. |
Moderately differentiated | 1.91 (1.42, 2.56) < 0.001 | 1.57 (1.30, 1.89) < 0.001 |
Poorly differentiated | 3.96 (2.99, 5.23) < 0.001 | 2.46 (2.06, 2.95) < 0.001 |
Undifferentiated; anaplastic | 3.82 (2.35, 6.20) < 0.001 | 2.64 (1.86, 3.74) < 0.001 |
Chemotherapy | ||
No/unknown | Ref. | Ref. |
Yes | 1.33 (1.19, 1.50) < 0.001 | 0.99 (0.90, 1.08) 0.776 |
LND | ||
LND1(< 0.1) | Ref. | Ref. |
LND2(>= 0.1, < 0.4) | 3.98 (3.45, 4.60) < 0.001 | 2.88 (2.59, 3.20) < 0.001 |
LND3(> = 0.4) | 8.57 (7.48, 9.82) < 0.001 | 5.54 (4.99, 6.15) < 0.001 |