Skip to main content

Table 3 Univariable and multivariable Cox regression analysis of CSS for nomogram in the training cohort

From: Establishment and validation of a postoperative predictive model for patients with colorectal mucinous adenocarcinoma

Variable

Univariate analysis

Multivariate analysis

HR (95% CI)

P

HR (95% CI)

P

Age

 <60

1

 

1

<0.001

 ≥60

1.17 (1.01–1.35)

0.036

1.55 (1.34–1.8 )

Sex

 Male

1

   

 Female

1.05 (0.92–1.19)

0.486

 

Race

 Black

1

   

 White

0.86 (0.7–1.05)

0.129

 

 Others (AI, API)

0.85 (0.64–1.13)

0.269

 

Martial status

 Unmarried

1

 

1

0.2546

 Married

0.88 (0.77–1)

0.045

0.93 (0.81–1.06)

Primary site

 Left colona

1

 

1

 

 Right colonb

0.88 (0.75–1.03)

0.103

 

 Overlapping lesion of colon

1.51 (0.99–2.3)

0.055

 

 Rectumc

1.18 (0.9–1.55)

0.231

 

Tumor size (mm)

 ≤50

1

 

1

0.1026

 >50

1.35 (1.18–1.54)

<0.001

1.12 (0.98–1.29)

Grade

 Grade I/II

1

 

1

0.0012

 Grade III/IV

2.06 (1.79–2.36)

<0.001

1.27 (1.1–1.47)

pT stage

 pT1

1

 

1

 

 pT2

1.35 (0.56–3.26)

0.507

1.09 (0.45–2.65)

0.8423

 pT3

3.85 (1.72–8.62)

0.001

1.8 (0.8–4.07)

0.1562

 pT4

11.64 (5.2–26.05)

<0.001

2.94 (1.29–6.69)

0.0102

pN stage

 pN0

1

 

1

 

 pN1

3.14 (2.62-3.77)

<0.001

2.1 (1.71–2.58)

<0.001

 pN2

7.21 (6.08-8.56)

<0.001

3.5 (2.84–4.32)

<0.001

M stage

 M0

1

1

 

<0.001

 M1

8.21 (7.18-9.4)

<0.001

3.58 (3.04–4.22)

CEA

 Negative

1

 

1

<0.001

 Positive

2.55 (2.22-2.93)

<0.001

1.54 (1.33–1.79)

PNI

 Negative

1

  

0.0398

 Positive

2.95 (2.52-3.45)

<0.001

1.19 (1.01–1.41)

TD

 Negative

1

  

<0.001

 Positive

4.52 (3.94-5.18)

<0.001

1.51 (1.29–1.76)

RNE

 <12

1

  

<0.001

 ≥12

0.48 (0.39-0.58)

<0.001

0.65 (0.53–0.79)

Chemotherapy

 No/Unknown

1

 

1

0.001

 Yes

2.19 (1.91-2.5)

<0.001

0.77 (0.66–0.9)

  1. CEA carcinoembryonic antigen, PNI perineural invasion, TD tumor deposits, RNE regional nodes examined
  2. aSplenic flexure, descending colon, and sigmoid colon
  3. bCecum, ascending colon, hepatic flexure, and transverse colon
  4. cRectum and rectosigmoid junction