Table 1 CRMA patients’ demographics and pathological characteristics in the development and validation cohort
Characteristics | Total (n=4711), n (%) | Training group (n=3299), n (%) | Validation group (n=1412), n (%) | P value |
|---|---|---|---|---|
Age | ||||
 <60 | 1422 (30.2) | 1001 (30.3) | 421 (29.8) | 0.744 |
 ≥60 | 3289 (69.8) | 2298 (69.7) | 991 (70.2) | |
Sex | ||||
 Male | 2297 (48.8) | 1597 (48.4) | 700 (49.6) | 0.483 |
 Female | 2414 (51.2) | 1702 (51.6) | 712 (50.4) | |
Race | ||||
 Black | 505 (10.7) | 359 (10.9) | 146 (10.3) | 0.706 |
 White | 3799 (80.6) | 2650 (80.3) | 1149 (81.4) | |
 Others (AI, API) | 407 (8.6) | 290 (8.8) | 117 (8.3) | |
Marital.status | ||||
 Unmarried | 2135 (45.3) | 1527 (46.3) | 608 (43.1) | 0.045 |
 Married | 2576 (54.7) | 1772 (53.7) | 804 (56.9) | |
Tumor site | ||||
 Left colona | 1040 (22.1) | 733 (22.2) | 307 (21.7) | 0.069 |
 Right colonb | 3257 (69.1) | 2299 (69.7) | 958 (67.8) | |
 Overlapping lesion of colon | 89 (1.9) | 60 (1.8) | 29 (2.1) | |
 Rectumc | 325 (6.9) | 207 (6.3) | 118 (8.4) | |
Grade | ||||
 Grade I/II | 3674 (78.0) | 2568 (77.8) | 1106 (78.3) | 0.741 |
 Grade III/IV | 1037 (22.0) | 731 (22.2) | 306 (21.7) | |
pT stage | ||||
 pT1 | 117 (2.5) | 93 (2.8) | 24 (1.7) | 0.073 |
 pT2 | 504 (10.7) | 348 (10.5) | 156 (11.0) | |
 pT3 | 2821 (59.9) | 1989 (60.3) | 832 (58.9) | |
 pT4 | 1269 (26.9) | 869 (26.3) | 400 (28.3) | |
pN stage | ||||
 pN0 | 2332 (49.5) | 1652 (50.1) | 680 (48.2) | 0.177 |
 pN1 | 1283 (27.2) | 904 (27.4) | 379 (26.8) | |
 pN2 | 1096 (23.3) | 743 (22.5) | 353 (25.0) | |
M stage | ||||
 M0 | 3878 (82.3) | 2734 (82.9) | 1144 (81.0) | 0.137 |
 M1 | 833 (17.7) | 565 (17.1) | 268 (19.0) | |
Tumor size (mm) | ||||
 ≤50 | 2011 (42.7) | 1416 (42.9) | 595 (42.1) | 0.641 |
 >50 | 2700 (57.3) | 1883 (57.1) | 817 (57.9) | |
CEA | ||||
 Negative | 2340 (49.7) | 1671 (50.7) | 669 (47.4) | 0.043 |
 Positive | 2371 (50.3) | 1628 (49.3) | 743 (52.6) | |
PNI | ||||
 Negative | 4157 (88.2) | 2924 (88.6) | 1233 (87.3) | 0.219 |
 Positive | 554 (11.8) | 375 (11.4) | 179 (12.7) | |
TD | ||||
 Negative | 3885 (82.5) | 2738 (83.0) | 1147 (81.2) | 0.157 |
 Positive | 826 (17.5) | 561 (17.0) | 265 (18.8) | |
RNE | ||||
 <12 | 382 (8.1) | 251 (7.6) | 131 (9.3) | 0.062 |
 ≥12 | 4329 (91.9) | 3048 (92.4) | 1281 (90.7) | |
Chemotherapy | ||||
 None/unknown | 2622 (55.7) | 1851 (56.1) | 771 (54.6) | 0.357 |
 Yes | 2089 (44.3) | 1448 (43.9) | 641 (45.4) | |