Fig. 4

Effects of sh-circ_0000808 and in-miR-1827 on NSCLC cell proliferation, apoptosis, migration, and invasion. A The transfection efficiency of in-miR-1827 was confirmed by measuring miR-1827 expression using qRT-PCR. B–J A549 and NCI-H1299 cells were transfected with sh-NC, sh-circ_0000808, sh-circ_0000808 + in-miR-NC, or sh-circ_0000808 + in-miR-1827. Cell proliferation was determined using CCK8 assay (B–C), colony formation assay (D), and EdU staining (E). Cell apoptosis, migration, and invasion were evaluated using flow cytometry (F), wound healing assay (G), and transwell assay (H). I–J WB analysis was used to examine the protein levels of ki67, Bax, and E-cadherin. *P < 0.05, **P < 0.01, ***P < 0.001