Fig. 2
From: Neoantigens and their clinical applications in human gastrointestinal cancers
Development of a personalized approach for targeting GI neoantigens by CAR-T cell-based vaccine. A personalized approach for targeting GI neoantigens might be impressive due to foremost advances in genetic engineering for expansion of autologous T cells and development of neoantigen specific-CAR-T cells (as vaccines encoding marked neoantigens). The specific approaches as combined with other therapies such as immune checkpoint inhibitors and anti PD-1 and CTLA-4 may be more effective for elimination of GI tumors