Table 4 Multivariate Cox regression analyses for DFS and OS of GC patients

Age (years)

 < 58

Ref.

Ref.

 ≥ 58

1.12

0.94–1.33

0.225

1.34

1.12–1.61

0.002

Tumor location

 GEJ + Upper 1/3

Ref.

Ref.

 Middle 1/3

1.02

0.82–1.27

0.845

1.05

0.84–1.31

0.691

 Lower 1/3

0.86

0.70–1.05

0.139

0.88

0.72–1.08

0.230

Tumor size

 < 3.2 cm

Ref.

Ref.

 ≥ 3.2 cm

1.17

0.96–1.42

0.122

1.17

0.95–1.43

0.133

Histologic grade

 Well-moderately

Ref.

Ref.

 Poorly

1.12

0.87–1.44

0.382

1.07

0.83–1.38

0.606

T category

 T1

Ref.

Ref.

 T2

1.79

1.07–3.00

0.026

1.94

1.13–3.35

0.017

 T3

2.93

1.75–4.92

< 0.001

3.31

1.92–5.71

< 0.001

 T4a

4.68

2.92–7.50

< 0.001

5.54

3.36–9.13

< 0.001

 T4b

6.68

3.54–12.60

< 0.001

8.99

4.63–17.44

< 0.001

N category

 N0

Ref.

Ref.

 N1

1.61

1.15–2.26

0.006

1.69

1.20–2.39

0.003

 N2

2.58

1.88–3.52

< 0.001

2.46

1.78–3.40

<0.001

 N3a

4.70

3.46–6.38

< 0.001

4.78

3.49–6.55

< 0.001

 N3b

7.18

4.99–10.33

< 0.001

7.97

5.48–11.60

< 0.001

VELIPI

 Negative

Ref.

Ref.

 Positive

1.27

1.03–1.57

0.027

1.11

0.89–1.37

0.357

Adjuvant treatment

 No

Ref.

Ref.

 Single drugs

0.62

0.45–0.84

0.002

0.57

0.41–0.79

0.001

 Double drugs

0.55

0.41–0.72

< 0.001

0.56

0.42–0.75

< 0.001

 Triple drugs

0.64

0.47–0.88

0.005

0.58

0.42–0.81

0.001

 CRT

0.66

0.47–0.94

0.021

0.60

0.42–0.86

0.005

TD

 Absent

Ref.

Ref.

 Present

1.75

1.42–2.14

< 0.001

1.93

1.57–2.38

< 0.001