Table 4 Multivariate Cox regression analysis of OS and DFS for all included patients

TNM (I, II, or III)

1.002

0.355–2.829

0.997

Lymph node metastasis (no vs yes)

2.139

0.714–6.408

0.174

1.574

0.705–3.513

0.268

Tumor size (≤ 2 cm vs > 2 cm)

2.636

0.865–8.026

0.088

2.461

0.975–6.212

0.057

ER (negative vs positive)

0.572

0.236–1.388

0.217

0.636

0.289–1.398

0.260

HER-2 (negative vs positive)

1.566

0.996–2.464

0.052

1.633

1.104–2.416

0.014*

PBK/TOPK (low vs high)

3.065

1.091–8.610

0.034*

2.091

0.918–4.764

0.079