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Table 1 The clinicopathological characteristics of included patients and their correlations with the expression of PBK/TOPK

From: Overexpression of PBK/TOPK relates to poor prognosis of patients with breast cancer: a retrospective analysis

Parameter

Total, N (%)

PBK/TOPK

(n = 202)

Low, N (%)

High, N (%)

rs

P

Age

 ≤ 50 y

94 (46.5)

52 (55.3)

42 (44.7)

−0.049

0.487

 > 50 y

108 (53.5)

65 (60.2)

43 (39.8)

  

Menopausal state

 Premenopausal

115 (56.9)

63 (54.8)

52 (45.2)

−0.073

0.301

 Postmenopausal

87(43.1)

54 (62.1)

33 (37.9)

  

Tumor size

 ≤ 2 cm

95 (47.0)

61 (64.2)

34 (35.8)

  

 > 2 cm ≤ 5 cm

96 (47.6)

51 (53.1)

45 (46.9)

0.124

0.078

 > 5 cm

11 (5.4)

5 (45.5)

6 (54.5)

  

Histological

 G1

20 (9.9)

13 (65.0)

7 (35.0)

  

 G2

147 (72.8)

93 (63.3)

54 (36.7)

0.171

0.015*

 G3

35 (17.3)

11 (31.4)

24 (68.6)

  

TNM

 I

66 (32.7)

45 (68.2)

21 (31.8)

  

 II

95 (47.0)

54 (56.8)

41 (43.2)

0.175

0.013*

 III

41 (20.3)

18 (43.9)

23 (56.1)

  

Cancer thrombus

 No

172 (85.1)

103 (59.9)

69 (40.1)

0.095

0.178

 Yes

30 (14.9)

14 (46.7)

16 (53.3)

  

Lymph node metastasis

 No

113 (55.9)

76 (67.2)

37 (32.8)

0.213

0.002*

 Yes

89 (44.1)

41 (46.1)

48 (53.9)

  

Number of lymph nodes

 1–3

56 (27.7)

29 (51.8)

27 (48.2)

  

 4–9

20 (9.9)

10 (50.0)

10 (50.0)

0.241

0.001*

 ≥ 10

13 (6.5)

2 (15.4)

11 (84.6)

  

Estrogen receptor

 Negative

53 (26.2)

22 (41.5)

31 (58.5)

−0.198

0.005*

 Positive

149 (73.8)

95 (63.8)

54 (36.2)

  

Progesterone receptor

 Negative

110 (54.5)

56 (50.9)

54 (49.1)

−0.155

0.027*

 Positive

92 (45.5)

61 (66.3)

31 (33.7)

  

HER-2

 Negative

137 (67.8)

85 (62.0)

52 (38.0)

0.153

0.037*

 Positive

49 (24.2)

22 (44.9)

27 (55.1)

  

Ki-67

 Low expression

65 (32.2)

52 (80.0)

13 (20.0)

0.312

< 0.001*

 High expression

137 (67.8)

64 (46.7)

73 (53.3)

  

Molecular typing

 Luminal A

33 (16.3)

30 (90.9)

3 (9.1)

22.031^

< 0.001^

 Luminal B

74 (36.6)

43 (58.1)

31 (41.9)

  

 HER-2(+)

49 (24.2)

22 (44.9)

27 (55.1)

  

 TNBC

30 (14.9)

12 (40.0)

18 (60.0)

  
  1. *Spearman correlation statistical analysis
  2. ^Chi-square test