Table 3 Correlation analysis between STMN1expression and immune cell markers in HCC
From: STMN1 as a novel prognostic biomarker in HCC correlating with immune infiltrates and methylation
Immune cells | Biomarkers | None | Purity | ||
|---|---|---|---|---|---|
Cor | P | Cor | P | ||
B cell | CD19 | 0.309 | *** | 0.375 | *** |
CD27 | 0.262 | *** | 0.390 | *** | |
CD38 | 0.239 | *** | 0.343 | *** | |
CD79A | 0.163 | *** | 0.278 | *** | |
T cell (general) | CD3D | 0.271 | *** | 0.390 | *** |
CD3E | 0.209 | *** | 0.365 | *** | |
CD2 | 0.209 | *** | 0.351 | *** | |
CD8+ T cell | CD8A | 0.238 | *** | 0.351 | *** |
CD8B | 0.231 | *** | 0.336 | *** | |
Tfh | CXCR3 | 0.269 | *** | 0.385 | *** |
CXCR5 | 0.191 | *** | 0.300 | *** | |
BCL6 | 0.131 | ** | 0.119 | ** | |
ICOS | 0.283 | *** | 0.400 | *** | |
Th1 | IFN-γ (IFNG) | 0.296 | *** | 0.376 | *** |
TNF-α (TNF) | 0.230 | *** | 0.347 | *** | |
IL12RB2 | 0.215 | *** | 0.247 | *** | |
STAT4 | 0.240 | *** | 0.304 | *** | |
STAT1 | 0.333 | *** | 0.370 | *** | |
CD94 (KLRD1) | 0.098 | ** | 0.178 | *** | |
BET (TBX21) | 0.123 | ** | 0.224 | *** | |
Th2 | STAT6 | 0.150 | *** | 0.129 | ** |
CCR3 | 0.262 | *** | 0.329 | *** | |
CD4 | 0.274 | *** | 0.365 | *** | |
STAT5A | 0.291 | *** | 0.337 | *** | |
Th9 | IRF4 | 0.221 | *** | 0.337 | *** |
SPI1 | 0.337 | *** | 0.499 | *** | |
Th22 | CCR10 | 0.446 | *** | 0.479 | *** |
Treg | CD25 (IL2RA) | 0.247 | *** | 0.383 | *** |
CCR8 | 0.313 | *** | 0.392 | *** | |
FOXP3 | 0.146 | *** | 0.217 | *** | |
Exhausted T cell | PD-1 (PDCD1) | 0.301 | *** | 0.403 | *** |
Tim-3 (HAVCR2) | 0.319 | *** | 0.470 | *** | |
CTLA4 | 0.327 | *** | 0.441 | *** | |
LAG3 | 0.328 | *** | 0.376 | *** | |
GZMB | 0.156 | *** | 0.220 | *** | |
M1 macrophage | INOS (NOS2) | −0.019 | 0.712 | −0.012 | 0.829 |
IRF5 | 0.354 | *** | 0.338 | *** | |
COX2 (PTGS2) | 0.080 | 0.125 | 0.202 | *** | |
M2 macrophage | CD163 | 0.111 | *** | 0.216 | *** |
ARG1 | −0.164 | *** | −0.162 | *** | |
VSIG4 | 0.131 | ** | 0.239 | *** | |
MS4A4A | 0.146 | *** | 0.278 | *** | |
TAM | CD80 | 0.336 | *** | 0.443 | *** |
PDCD1LG2 | 0.128 | ** | 0.241 | *** | |
CD40 | 0.299 | *** | 0.312 | *** | |
TLR7 | 0.248 | *** | 0.362 | *** | |
CCL2 | 0.097 | ** | 0.208 | *** | |
IL10 | 0.201 | *** | 0.302 | *** | |
Monocyte | CD86 | 0.316 | *** | 0.468 | *** |
CD115 (CSF1R) | 0.194 | *** | 0.334 | *** | |
NK cell | NCAM1 | 0.234 | *** | 0.315 | *** |
KIR2DL1 | 0.008 | 0.871 | −0.025 | 0.649 | |
KIR2DL3 | 0.209 | *** | 0.255 | *** | |
KIR2DL4 | 0.268 | *** | 0.294 | *** | |
KIR3DL1 | 0.070 | 0.176 | 0.076 | 0.158 | |
KIR3DL2 | 0.135 | *** | 0.180 | *** | |
KIR2DS4 | 0.116 | ** | 0.105 | ** | |
CD314 (KLRK1) | 0.153 | *** | 0.263 | *** | |
CD7 | 0.279 | *** | 0.369 | *** | |
XCL1 | 0.392 | *** | 0.433 | *** | |
Neutrophil | CD11b (ITGAM) | 0.287 | *** | 0.370 | *** |
CD15 (FUT4) | 0.338 | *** | 0.372 | *** | |
MPO | 0.112 | ** | 0.160 | *** | |
Dendritic cell | CD1C | 0.100 | ** | 0.198 | *** |
HLA-DPB1 | 0.220 | *** | 0.337 | *** | |
HLA-DQB1 | 0.188 | *** | 0.294 | *** | |