Fig. 4

The prognostic ability of IRGscore. a Survival analysis of melanoma patients with low and high IRGscore based on K-M curves (P < 0.0001, log-rank test). b Survival analysis of independent dataset of cutaneous melanoma patients with low and high IRGscore based on K-M curves (P < 0.05, log-rank test). c Age < = 65 (P = 0.022, log-rank test). d Age > 65 (P = 0.037, log-rank test). e Female (P = 0.012, log-rank test). f Male (P = 0.014, log-rank test). g Patients with stage T1-2 (P = 0.081, log-rank test). h Patients with stage T3-4 (P = 0.045, log-rank test). i Stratified survival analysis of patients derived from TCGA-SKCM cohort divided according to both IRGscores and TMB (P < 0.001, log-rank test)