Table 5 The characteristic clinicopathological features of the special HCC variants

1- Macrotrabecular massive (9%)

2019

Median age (60 years)

Male (78.3%)

HCV (96.8 %)

DAAs (42.9%)

Median AFP (300ng/dl)

Median size (6.00 cm)

Multifocal (21.7%)

Non-cirrhosis (31.1%)

Poor grade (37%)

Late stage (17.4%)

LVI (63%)

Recurrence (45.5%)

Mean OS ± SD (32.35 ± 5.23)

2- Clear cell HCC (6.7 %)

2010–2019

Median age (58 years)

Male (79.4%)

HCV (90.5%)

DAAs (37.5%)

Median AFP (28 ng/dl)

Median size (5.00 cm)

Multifocal (29.0%)

Non-cirrhosis (27.6%)

Poor grade (4 %)

Late stage (0 %)

LVI (33.3%)

Recurrence (0%)

Mean OS ± SD (41.05 ± 7.94)

3- Steatohepatitic HCC (2.9 %)

2019

Median age (59 years)

Male (86.7%)

HCV (91.7 %)

DAAs (37.5%)

Median AFP (16 ng/dl)

Median size (4.00 cm)

Multifocal (26.7%)

Non-cirrhosis (20%)

Poor grade (60%)

Late stage (7.1%)

LVI (42.9%)

Recurrence (16.7%)

Mean OS ± SD (78.36 ± 16.52)

4- Scirrhous HCC (2.2 %)

2010–2019

Median age (59 years)

Male (72.7 %)

HCV (88.9%)

DAAs (66.7%)

Median AFP (30 ng/dl)

Median size (4.00 cm)

Multifocal (27.3 %)

Non-cirrhosis (27.3%)

Poor grade (42.9%)

Late stage (0%)

LVI (57.1%)

Recurrence (33.3%)

Mean OS ± SD (17.57 ± 4.29)

5- Fibrolamellar HCC (FLC) (1.6%)

2010–2019

Median age (23 years)

Male (57.1%)

HCV (14.3%)

DAAs (NA)

Median AFP (9 ng/dl)

Median size (8.5 cm)

Multifocal (0%)

Non-cirrhosis (100%)

Poor grade (NA)

Late stage (0%)

LVI (33.3%)

Recurrence (66.7%)

Mean OS ± SD (72 ± 23)

6- Sarcomatoid HCC (2%)

2010

Median age (59 years)

Male (90%)

HCV (85.7%)

DAAs (100%)

Median AFP (62 ng/dl)

Median size (6.00 cm)

Multifocal (30%)

Non-cirrhosis (0%)

Poor grade (100%)

Late stage (33.3%)

LVI (25%)

Recurrence (33.3%)

Mean OS ± SD (36 ± 0.00)

7- Chromophobe HCC (0.8%)

2019

Median age (60 years)

Male (75%)

HCV (100%)

DAAs (75%)

Median AFP (22.5 ng/dl)

Median size (5.00 cm)

Multifocal (0%)

Non-cirrhosis (50%)

Poor grade (0%)

Late stage (0%)

LVI (50%)

Recurrence (25 %)

Mean OS ± SD (29.67 ± 5.99)

8- LEL-HCC (0.2%)

2010–2019

Median age (42 years)

Male (100%)

HCV (100%)

DAAs (0%)

Median AFP (2 ng/dl)

Median size (2.00 cm)

Multifocal (0 %)

Non-cirrhosis (100 %)

Poor grade (100%)

Late stage (0%)

LVI (0%)

Recurrence (0 %)

Mean OS ± SD (60 ± 0.00)

9- Neutrophils rich HCC (1%)

2019

Median age (60 years)

Male (80 %)

HCV (80 %)

DAAs (33.3 %)

Median AFP (22.5 ng/dl)

Median size (8.00 cm)

Multifocal (40%)

Non-cirrhosis (0%)

Poor grade (80 %)

Late stage (NA)

LVI (100 %)

Recurrence (50%)

Mean OS ± SD (6.5 ± 3.89)

10- cHCC-CC (0.6%)

2010–2019

Median age (59 years)

Male (100%)

HCV (100%)

DAAs (0%)

Median AFP (4000 ng/dl)

Median size (8.00 cm)

Multifocal (33.3%)

Non-cirrhosis (0%)

Poor grade (NA)

Late stage (100%)

LVI (66.7%)

Recurrence (NA)

Mean OS ± SD (1 ± 0.00)