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Table 1 General clinical, laboratory, and pathological data of HCC

From: The clinicopathological and prognostic factors of hepatocellular carcinoma: a 10-year tertiary center experience in Egypt

Parameters

n (%)

Clinical and laboratory

Median age (years) (n= 511)

58 years

 < 60

287 (57.1)

 ≥ 60

216 (42.9)

Gender (n= 511)

 Male

428 (83.8)

 Female

83 (16.2)

Etiology (n= 363)

 HCV

329 (90.6)

 HBV

4 (1.1)

 Combined HCV/HBV

2 (0.6)

 Non-viral

28 (7.7)

Previous HCV treatment (n= 221)

 IFN

30 (13.6)

 DAAs

123 (55.7)

 No

68 (30.8)

Median AFP (n= 300)

29 ng/dl

 AFP (≥ 20 ng/dl)

180 (60)

 AFP (≥ 200 ng/dl)

81 (27)

 AFP (≥ 400 ng/dl)

52 (17.3)

Macroscopic

Tumor focality (n= 492)

 Solitary

333 (67.7)

 Multiple

159 (32.3)

Median tumor size (n= 480)

5 cm

 Tumor size ≥ 2 cm

430 (89.6)

 Tumor size ≥ 5 cm

255 (53.1)

Microscopic

Pathological grade (n= 511)

 I

34 (6.6)

 II

357 (69.9)

 III

82 (16)

 Un

38 (7.5)

Pathological patterns of NOS (n= 375)

 Trabecular and acinar

341 (90.9)

 Solid

34 (9.1)

Tumor clear and fatty cell changes (n= 511)

 Absent

288 (56.4)

 Present

223 (43.6)

TILs Salgado classifications (n= 511)

 0–10

459 (89.8)

 20–40

51 (10.0)

 50–90

1 (0.2)

Intra-tumoral fibrous stroma (n= 511)

 Absent

344 (67.3)

 Present

167 (32.7)

Tumor necrosis (n= 511)

 Negative

360 (70.5)

 Positive

151 (29.5)

Pathological stage (n= 368)

 1a

24 (6.5)

 1b

121 (32.9)

 2

161 (43.8)

 3

49 (13.3)

 4

13 (3.5)

LVI (n= 372)

 Negative

201 (54.0)

 Positive

171 (46.0)

Bile duct invasion (n= 368)

 Negative

365 (99.2)

 Positive

3 (0.8)

Perineural invasion (n= 368)

 Negative

365 (99.2)

 Positive

3 (0.8)

LN status (n= 39)

 Negative

29 (74.4)

 Positive

10 (25.6)

  1. HCC hepatocellular carcinoma, HCV hepatitis C virus, HBV hepatitis B virus, IFN interferon, DAAs direct acting anti-viral, AFP alpha-fetoprotein, TILs tumor-infiltrating lymphocytes, LVI lymphovascular invasion, LN lymph node. Data were missed in some cases; we figured out the number beside each parameter