Local recurrence of mammary Paget’s disease after nipple-sparing mastectomy and implant breast reconstruction: a case report and literature review

Table 1 Summary of reported cases of local recurrence as Paget’s disease after NSM with primary reconstruction [2, 8,9,10,11]

Authors	Number of patients reported	Patient		Primary tumor	TTR (months)	Recurrence tumor		Treatment
Authors	Number of patients reported	No	Age (years)	ER/PR/Her-2	TTR (months)	Histotype	ER/PR/Her-2	Treatment
Zhen-Yu Wu et al. [2]	19/944	1	40s	N/N/P	135	Paget	N/N/P	Excision
		2	30s	N/N/P	30	Paget	NA	Excision
		3	20s	N/N/P	35	Paget	N/N/P	Excision and RT
		4	40s	P/P/P	77	Paget	P/N/P	Excision
		5	30s	N/N/P	29	DCIS and Paget	N/N/P	Excision
		6	30s	N/N/P	43	DCIS and Paget	NA	Excision
		7	40s	N/N/P	61	DCIS and Paget	N/N/P	Excision
		8	40s	N/N/P	23	DCIS and Paget	N/N/P	Excision
		9	40s	P/N/N	25	DCIS and Paget	NA	Excision and HT
		10	30s	N/N/P	44	DCIS and Paget	N/N/P	Excision
		11	30s	N/N/P	24	DCIS and Paget	N/N/P	Excision
		12	30s	N/N/P	25	DCIS and Paget	N/N/P	Excision
		13	30s	N/N/P	23	DCIS and Paget	N/N/P	Excision
		14	40s	N/N/P	51	DCIS and Paget	N/N/P	Excision and RT
		15	30s	P/P/P	54	microDCIS + Paget	N/N/P	Excision and HT
		16	30s	N/N/P	36	DCIS and Paget	N/N/P	Excision, RT, CTx, Hercetin
		17	30s	N/N/P	18	DCIS and Paget	NA	Excision
		18	40s	P/P/P	35	DCIS and Paget	P/N/P	Excision
		19	30s	N/N/P	15	Paget	N/N/P	Excision
Shearman CP, et al. [9]	3/584	20	41	NA	18	Paget	NA	Excision
		21	51	NA	18	Paget	NA	Excision
		22	50	NA	48	Paget	NA	Excision
Mendez-Fernandez, et al. [10]		23	53	NA	96	Paget	NA	Excision
Harness JK, et al. [11]	1/43	24	NA	NA	34	Paget	NA	Excision
Lohsiriwat V et al. [8]	7/861	25	53	N/N/N	43	Paget and DIN	NA	Excision
		26	38	N/N/P	47	DCIS and Paget	NA	Excision and RT
		27	48	N/N/P	48	Paget	NA	Excision
		28	44	N/N/P	12	Paget and DIN	NA	Excision
		29	38	N/N/P	27	Paget	NA	Excision
		30	37	N/N/P	49	Paget and DIN	NA	Excision
		31	42	N/N/P	22	Paget	NA	Excision
Present study	1	32	30	P/P/N	120	DCIS and Paget	N/N/P	Excision and HT

Abbreviations: DCIS Ductal carcinoma in situ, DIN Ductal intraepithelial neoplasia, ER Estrogen receptor, PR Progesterone receptor, N Negative, P Positive, NA Not applicable, TTR Time to recurrence, RT Radiation therapy, HT Hormonal therapy, CTx Chemotherapy

ISSN: 1477-7819