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Table 3 Response Operating Characteristic (ROC) curve analysis for prediction of LN metastasis using galectins, CA 125 or CA 19.9

From: Assessment of galectins -1, -3, -4, -8, and -9 expression in ovarian carcinoma patients with clinical implications

 

Marker

ROC parameter

Gal-1

Gal-3

Gal-4

Gal-8

Gal-9

CA 125

CA 19.9

AUC

0.599

0.665

0.639

0.610

0.703

0.608

0.503

SE

0.076

0.073

0.080

0.076

0.072

0.076

0.120

95% CI

0.459 to 0.728

0.526 to 0.786

0.500 to 0.763

0.471 to 0.738

0.566 to 0.818

0.469 to 0.736

0.309 to 0.696

z statistic

1.300

2.257

1.747

1.448

2.826

1.418

0.023

P value (AUC = 0.5)

0.194

0.024

0.081

0.148

0.005

0.156

0.982

Youden index J

0.33

0.38

0.28

0.33

0.33

0.304

0.167

Associated criterion

> 1234.7

> 379.3

> 0.7

> 189.7

> 1234.7

> 134.1

> 150

Sensitivity (%)

38

43

76

43

43

57

17

Specificity (%)

95

95

53

89

89

74

100

  1. AUC area under curve, ROC response operating characteristic, SE standard error
  2. All p values are unadjusted as calculated with the DeLong method. P < 0.006 is considered statistically significant (Boneferroni method)