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Table 3 Response Operating Characteristic (ROC) curve analysis for prediction of LN metastasis using galectins, CA 125 or CA 19.9

From: Assessment of galectins -1, -3, -4, -8, and -9 expression in ovarian carcinoma patients with clinical implications

  Marker
ROC parameter Gal-1 Gal-3 Gal-4 Gal-8 Gal-9 CA 125 CA 19.9
AUC 0.599 0.665 0.639 0.610 0.703 0.608 0.503
SE 0.076 0.073 0.080 0.076 0.072 0.076 0.120
95% CI 0.459 to 0.728 0.526 to 0.786 0.500 to 0.763 0.471 to 0.738 0.566 to 0.818 0.469 to 0.736 0.309 to 0.696
z statistic 1.300 2.257 1.747 1.448 2.826 1.418 0.023
P value (AUC = 0.5) 0.194 0.024 0.081 0.148 0.005 0.156 0.982
Youden index J 0.33 0.38 0.28 0.33 0.33 0.304 0.167
Associated criterion > 1234.7 > 379.3 > 0.7 > 189.7 > 1234.7 > 134.1 > 150
Sensitivity (%) 38 43 76 43 43 57 17
Specificity (%) 95 95 53 89 89 74 100
  1. AUC area under curve, ROC response operating characteristic, SE standard error
  2. All p values are unadjusted as calculated with the DeLong method. P < 0.006 is considered statistically significant (Boneferroni method)