Table 2 Univariate Cox regression analysis of factors associated with survival in locally advanced gastric cancer patients with neoadjuvant chemotherapy

Gender (female vs male)

0.53

0.32

2.73

1.70

0.91–3.19

.099

0.42

0.30

1.86

1.51

0.83–2.75

0.173

Age (< 65 y vs ≥ 65 y)

0.02

0.33

0.00

1.02

0.53–1.94

0.955

0.21

0.31

0.44

1.23

0.67–2.27

0.507

Tumor location (middle/lower vs upper)

0.34

0.28

1.50

1.41

0.81–2.45

0.220

0.23

0.26

0.77

1.26

0.76–2.09

0.379

NACT cycle (< 3 vs ≥ 3)

0.00

0.28

0.00

1.00

0.58–1.73

0.999

0.07

0.25

0.08

1.08

0.65–1.77

0.774

Histologic grade (poorly vs well/moderately)

0.75

0.35

4.54

2.12

1.06–4.23

.033

0.65

0.31

4.35

1.92

1.04–3.54

.037

Margin status (R1 vs R0)

0.72

0.39

3.50

2.06

0.97–4.38

.061

0.67

0.36

3.48

1.96

0.97–3.99

.062

TRG (3 vs 0–2)

0.95

0.31

9.13

2.58

1.40–4.79

.003

0.78

0.28

7.92

2.18

1.27–3.75

.005

Lymph node ratio (> 30% vs ≤ 30%)

2.10

0.30

49.19

8.21

4.56–14.78

< .001

1.87

0.26

50.11

6.48

3.86–10.86

< .001