| Serological biomarkers | Investigation sample size | Sensitivity | Specificity | Reference (PMID) |
---|---|---|---|---|---|
Classical biomarker | Fibrinogen (4.71 g/L) | 21/73 | 42.9% | 88.5% | 28131667 |
Serum pancreatic enzymes (lipase and amylase) | 54/203 | Cutoff values did not determined | 25239347 | ||
42/142 | 27394653 | ||||
Extracellular vesicle | MUC5 (10, DEST assay) | 34/123 | 100% | 82% | 33301777 |
MicroRNA | miR-223 (125.0 atto M) | 28/36 | 82.4% | 62.9% | 25819175 |
miR-1290 | 16/20 | Cutoff value did not determined (AUC = 0.82) | 23697990 | ||
miR-483-3p and miR-21 | 32/44 | Cutoff values did not determined (AUC = 0.703 and 0.603, respectively) | 25384963 | ||
Antibody | CEA (5.0 ng/ml) CA9-9 (37 U/ml) p53 antibody (1.3 U/ml) | 73/111 | 38.4% | 81.6% | 32541631 |
Antibodies to Fusobacterium nucleatum | 46/91 | Cutoff value did not determined | 32983143 |