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Table 3 Uni- and multivariate predictive factors of POPF after DP

From: The pancreas-to-muscle signal intensity ratio on T1-weighted MRI as a predictive biomarker for postoperative pancreatic fistula after distal pancreatectomy: a single-center retrospective study

  n Univariate Multivariate
OR 95% CI p-value OR 95% CI p-value
Preoperative Age (years)
 >70 45 0.79 0.32–1.89 0.61    
 <70 72 1      
Sex
 Male 68 1.24 0.53–3.01 0.62    
 Female 49 1      
BMI (kg/m2)
 >24 39 2.07 0.85–5.00 0.10    
 <24 77 1      
Pancreatic ductal adenocarcinoma
 Yes 55 0.74 0.31–1.72 0.48    
 No 62 1      
Location
 Body 68 0.59 0.25–1.37 0.22    
 Tail 49 1      
Pancreas-to-muscle SIR on T1-w MRI
 >1.37 61 29.7 5.83–543.73 <0.01 23.25 3.93–454.03 <0.01
 <1.37 41 1    1   
Intraoperative Operative time (min)
 >300 38 1.36 0.55–3.24 0.50    
 <300 78 1      
Blood loss (ml)
 >400 39 0.86 0.33–2.07 0.73    
 <400 77 1      
Surgical procedure
 Open 83 1.79 0.69–5.28 0.24    
 Laparoscopic 34 1      
 Spleen preserving 18 0.56 0.12–1.87 0.37    
 Non-spleen preserving 99 1      
Resection procedure
 Hand-sewn 47 0.88 0.36–2.07 0.78    
 Stapler 70 1      
Pancreas texture
 Soft 75 1.65 0.68–4.35 0.28    
 Hard 42 1      
Pancreas thickness (mm)
 >12 56 0.71 0.30–1.64 0.42    
 <12 61 1      
Postoperative D-Amy levels (U/l)—POD 1
 >7238 33 5.07 2.07–12.78 <0.01 1.21 0.31–4.75 0.78
 <7238 83 1    1   
D-Amy levels (U/l)—POD 3
 >737 51 4.99 2.04–13.25 <0.01 3.91 1.02–16.36 0.046
 <737 65 1    1   
WBC (×103/μl)—POD 1
 >1.20 48 3.16 1.34-7.75 <0.01 2.44 0.69–9.12 0.17
 <1.20 69 1    1   
WBC (×103/μl)—POD 3
 >1.40 34 2.59 1.07–6.29 0.04 1.03 0.27–3.73 0.96
 <1.40 83 1    1   
CRP (mg/dl)—POD 1
 >10 40 1.51 0.63–3.58 0.35    
 <10 77 1      
CRP (mg/dl)—POD 3
 >20 34 3.89 1.61–9.60 <0.01 2.75 0.75–10.70 0.13
 <20 83 1    1   
Body temperature (°C)—POD 1
 >38.0 71 0.74 0.32–1.75 0.49    
 <38.0 46 1      
Body temperature (°C)—POD 3
 >38.0 14 0.47 0.07–1.87 0.31    
 <38.0 103 1      
Heart rate (bpm)—POD 1
 >100 38 2.05 0.85–4.88 0.11    
 <100 79 1      
Heart rate (bpm)—POD 3
 >100 13 4.35 1.32–14.81 0.02 3.84 0.77–21.40 0.10
 <100 104 1    1   
  1. POPF Postoperative pancreatic fistula, OR Odds ratio, 95% CI 95% Confidence interval, BMI Body mass index, pancreas-to-muscle SIR on T1-w MRI the pancreas-to-muscle signal intensity ratio on unenhanced T1-weigthed magnetic resonance imaging, D-Amy drainage fluid amylase concentration, POD Postoperative day, WBC White blood cell, CRP C-reactive protein
  2. p < 0.05