Variables | All patients (n = 451) | Severe PHLF | P value | |
---|---|---|---|---|
No (n = 421) | Yes (n = 30) | |||
Age (years) | 71 (35–91) | 71 (35–91) | 68 (35–82) | 0.2788 |
Sex, female/male/female | 146/305 | 139/282 | 7/23 | 0.2734 |
BMI (kg/m2) | 23.2 (13.4–34.1) | 23.3 (13.4–34.1) | 21.6 (19.2–29.0) | 0.0237* |
Etiology HBV/HCV/HBV + HCV/NBNC | 65/280/5/101 | 59/259/5/98 | 6/21/0/3 | 0.3103 |
Albumin (g/dL) | 4.0 (2.5–5.1) | 4.0 (2.5–5.1) | 3.7 (3.0–4.9) | 0.0054* |
Total bilirubin (mg/dL) | 0.7 (0.2–2.0) | 0.7 (0.2–2.0) | 1.0 (0.4–1.9) | 0.0012* |
AST (IU/L) | 37 (8–252) | 36 (8–252) | 55 (32–150) | < 0.0001** |
ALT (IU/L) | 34 (6–312) | 33 (6–312) | 47 (20–245) | 0.0004** |
Platelet count (× 109/L) | 134 (24–660) | 139 (24–530) | 89 (33–660) | 0.0019* |
PT (%) | 91.5 (46.3–130.3) | 91.9 (46.3–130.3) | 82.3 (49.2–107.9) | 0.0019* |
INR | 1.06 (0.88–1.67) | 1.05 (0.88–1.67) | 1.11 (0.97–1.56) | 0.0023* |
Creatinine (mg/dL) | 0.76 (0.20–7.11) | 0.76 (0.2–7.11) | 0.84 (0.5–6.0) | 0.0152* |
Urine nitrogen (mg/dL) | 14.8 (5.3–48.9) | 14.8 (5.3–48.9) | 14.7 (9.3–47.5) | 0.6681 |
ICG-R15 (%) | 16.8 (0.9–67.0) | 16.5 (0.9–67.0) | 24.0 (3.9–54.6) | 0.0068* |
PALBI | − 2.66 (− 3.43 to − 1.31) | − 2.67 (− 3.43 to − 1.65) | (− 2.45 (− 3.14 to (− 1.31) | 0.0055* |
APRI | 0.96 (0.09–12.7) | 0.91 (0.09–12.7) | 2.16 (0.19–8.99) | < 0.0001** |
FIB-4 index | 3.3 (0.5–100.6) | 3.2 (0.5–100.6) | 6.5 (0.7–22.2) | < 0.0001** |
ALPlat index | 500 (322–975) | 504 (322–932) | 466 (331–975) | 0.0016* |
MELD | 7.3 (6.4–15.5) | 7.3 (6.4–15.1) | 8.9 (6.4–15.5) | 0.0005** |
Child-Pugh grade A/B | 438/13 | 410/11 | 28/2 | 0.1998 |
Blood loss (mL) | 270 (0–3330) | 260 (0–2800) | 695 (33–3330) | 0.0003** |
Operating time (min) | 214 (60–633) | 212 (60–630) | 276 (90–633) | 0.0014* |
Extent of hepatectomy Minor/major | 406/45 | 384/37 | 22/8 | 0.0016* |
AFP (ng/mL) | 11.7 (1.0–93721) | 11.2 (1.0–46262.6) | 39.3 (2.1–93721) | 0.0014* |
DCP (mAU/mL) | 24 (0.01–109830) | 24 (0.01–43253) | 42 (0.03–109830) | 0.1851 |
BCLC grading 0/A/B | 109/261/81 | 105/245/71 | 4/16/10 | 0.0522 |
TNM staging I–II/III–IV | 213/238 | 206/215 | 7/23 | 0.0114* |
Tumor size (cm) | 2.4 (0.5–13.0) | 2.3 (0.5–13.0) | 3.0 (1.5–12.0) | 0.0069* |
Solitary/multiple | 326/125 | 309/112 | 17/13 | 0.0479* |
Poorly differentiation | 114 (25.3%) | 105 (24.9%) | 9 (30.0%) | 0.5379 |
Microscopic vascular invasion | 35 (7.8%) | 34 (8.1%) | 1 (3.3%) | 0.3482 |
Microscopic intrahepatic metastasis | 63 (14.0) | 55 (13.1%) | 8 (26.7%) | 0.0379* |
Liver cirrhosis (F4) | 206 (45.7%) | 187 (44.4%) | 19 (63.3%) | 0.0445* |