Table 5 Correlation analysis between IL17A and relate markers of immune cells
From: Prognostic biomarker IL17A correlated with immune infiltrates in head and neck cancer
Cell subtype | Gene markers | None | Purity | ||
|---|---|---|---|---|---|
Cor. | P. | Cor. | P. | ||
CD8+ T cell | CD8A | 0.323 | 0.000 | 0.309 | 0.000 |
| Â | CD8B | 0.293 | 0.000 | 0.278 | 0.000 |
T cell | CD3D | 0.360 | 0.000 | 0.347 | 0.000 |
| Â | CD3E | 0.366 | 0.000 | 0.354 | 0.000 |
| Â | CD2 | 0.372 | 0.000 | 0.359 | 0.000 |
B cell | CD19 | 0.398 | 0.000 | 0.387 | 0.000 |
| Â | CD79A | 0.410 | 0.000 | 0.399 | 0.000 |
Monocyte | CD86 | 0.192 | 0.000 | 0.171 | 0.000 |
| Â | CSF1R | 0.224 | 0.000 | 0.204 | 0.000 |
TAM | CCL2 | 0.231 | 0.000 | 0.213 | 0.000 |
| Â | CD68 | 0.098 | 0.029 | 0.082 | 0.068 |
| Â | IL10 | 0.297 | 0.000 | 0.281 | 0.000 |
M1 | NOS2 | 0.273 | 0.000 | 0.283 | 0.000 |
| Â | IRF5 | 0.120 | 0.008 | 0.120 | 0.008 |
| Â | PTGS2 | 0.114 | 0.012 | 0.125 | 0.006 |
M2 | CD163 | 0.145 | 0.001 | 0.122 | 0.007 |
| Â | VSIG4 | 0.059 | 0.194 | 0.034 | 0.455 |
| Â | MS4A4A | 0.127 | 0.005 | 0.103 | 0.022 |
Neutrophils | CEACAM8 | 0.093 | 0.040 | 0.097 | 0.032 |
| Â | ITGAM | 0.179 | 0.000 | 0.167 | 0.000 |
| Â | CCR7 | 0.381 | 0.000 | 0.370 | 0.000 |
| Â | KIR2DL1 | 0.123 | 0.006 | 0.114 | 0.011 |
| Â | KIR2DL3 | 0.137 | 0.002 | 0.125 | 0.006 |
| Â | KIR2DL4 | 0.217 | 0.000 | 0.203 | 0.000 |
| Â | KIR3DL1 | 0.217 | 0.000 | 0.205 | 0.000 |
| Â | KIR3DL2 | 0.222 | 0.000 | 0.211 | 0.000 |
| Â | KIR2DS4 | 0.082 | 0.069 | 0.068 | 0.132 |
Dendritic cell | HLA-DPB1 | 0.270 | 0.000 | 0.253 | 0.000 |
| Â | HLA-DQB1 | 0.238 | 0.000 | 0.222 | 0.000 |
| Â | HLA-DRA | 0.275 | 0.000 | 0.258 | 0.000 |
| Â | HLA-DPA1 | 0.263 | 0.000 | 0.246 | 0.000 |
| Â | CD1C | 0.243 | 0.000 | 0.225 | 0.000 |
| Â | NRP1 | 0.025 | 0.576 | 0.004 | 0.924 |
| Â | ITGAX | 0.208 | 0.000 | 0.188 | 0.000 |
Th1 | TBX21 | 0.317 | 0.000 | 0.303 | 0.000 |
| Â | STAT4 | 0.188 | 0.000 | 0.168 | 0.000 |
| Â | STAT1 | 0.180 | 0.000 | 0.161 | 0.000 |
|  | IFN-γ (IFNG) | 0.329 | 0.000 | 0.315 | 0.000 |
|  | TNF-α (TNF) | 0.284 | 0.000 | 0.275 | 0.000 |
Th2 | GATA3 | 0.144 | 0.001 | 0.125 | 0.005 |
| Â | STAT6 | 0.135 | 0.003 | 0.143 | 0.002 |
| Â | STAT5A | 0.268 | 0.000 | 0.258 | 0.000 |
| Â | IL13 | 0.284 | 0.000 | 0.273 | 0.000 |
Tfh | BCL6 | 0.083 | 0.066 | 0.103 | 0.023 |
| Â | IL21 | 0.355 | 0.000 | 0.344 | 0.000 |
Th17 | STAT3 | 0.285 | 0.000 | 0.285 | 0.000 |
| Â | IL17A | 1.000 | 0.000 | -1.000 | 0.000 |
Treg | FOXP3 | 0.333 | 0.000 | 0.320 | 0.000 |
| Â | CCR8 | 0.331 | 0.000 | 0.318 | 0.000 |
| Â | STAT5B | 0.165 | 0.000 | 0.161 | 0.000 |
|  | TGF-β (TGFB1) | − 0.083 | 0.067 | − 0.099 | 0.029 |
T cell exhaustion | PD-1 (PDCD1) | 0.336 | 0.000 | 0.322 | 0.000 |
| Â | CTLA4 | 0.355 | 0.000 | 0.342 | 0.000 |
| Â | LAG3 | 0.255 | 0.000 | 0.239 | 0.000 |
| Â | HAVCR2 | 0.197 | 0.000 | 0.176 | 0.000 |
| Â | GZMB | 0.281 | 0.000 | 0.265 | 0.000 |