Table 3 Signaling pathways most significantly correlated with IL17A expression based on their NES and FDR

Positive

Immunoglobulin complex

3.000

0.001

0.028

T cell receptor complex

2.848

0.001

0.028

Antigen binding

2.829

0.001

0.028

Immunoglobulin production

2.799

0.001

0.028

Humoral immune response mediated by circulating immunoglobulin

2.793

0.001

0.028

Negative

Co-translational protein targeting to membrane

− 2.337

0.006

0.073

Establishment of protein localization to endoplasmic reticulum

− 2.346

0.007

0.078

Nuclear transcribed mRNA catabolic process nonsense mediated decay

− 2.389

0.008

0.081

Large ribosomal subunit

− 2.437

0.007

0.078

Structural constituent of ribosome

− 2.545

0.010

0.097

KEGG ID

NES

p value

FDR

Positive

Primary immunodeficiency

2.205

0.001

0.026

Antigen processing and presentation

2.199

0.001

0.026

Cytokine-cytokine receptor interaction

2.181

0.001

0.026

Intestinal immune network for IgA production

2.180

0.001

0.026

Hematopoietic cell lineage

2.171

0.001

0.026

Negative

Porphyrin and chlorophyll metabolism

− 1.691

0.011

0.081

Metabolism of xenobiotics by cytochrome p450

− 1.712

0.014

0.096

Ascorbate and aldarate metabolism

− 1.795

0.006

0.060

Pentose and glucuronate interconversions

− 1.830

0.003

0.044

Ribosome

− 2.458

0.006

0.060