Prognostic factors in colorectal liver metastases patients with various tumor numbers treated by liver resection: a single-center, retrospective study

Table 3 Results of multivariable analysis of predictors for overall survival in three subgroups

	Risk factors	Preoperative factors
	Risk factors	HR	95%CI	p
N = 1	Primary site
(n = 375)	Left	Ref
	Right	1.724	1.167–2.546	0.006
	Pulmonary metastases
	Negative	Ref
	Positive	1.915	1.179–3.109	0.009
	RAS mutation
	Wild	Ref
	Mutation	1.942	1.374–2.744	0.000
	CEA level (ng/ml)
	< 200	Ref
	≥ 200	4.444	2.071–9.536	0.000
	CA19–9 level (IU/ml)
	< 50	Ref
	≥ 50	2.289	1.593–3.289	0.000
N = 2–4	Primary tumor T stage
(n = 424)	T₁₋₂	Ref
	T₃₋₄	3.851	1.689–8.781	0.001
	Primary tumor lymph node status
	Negative	Ref
	Positive	1.670	1.183–2.358	0.004
	Maximum tumor diameter
	< 5 cm	Ref
	≥ 5 cm	2.000	1.309–3.056	0.001
	Pulmonary metastases
	Negative	Ref
	Positive	1.711	1.113–2.630	0.014
	RAS mutation
	Wild	Ref
	Mutation	1.456	1.059–2.003	0.021
	CA19-9 level (IU/ml)
	< 50	Ref
	≥ 50	1.863	1.313–2.642	0.001
N ≥ 5	Primary tumor lymph node status
(n = 296)	Negative	Ref
	Positive	1.984	1.275–3.087	0.002
	Maximum tumor diameter
	< 5 cm	Ref
	≥ 5 cm	2.260	1.302–3.923	0.004
	RAS mutation
	Wild	Ref
	Mutation	3.150	2.153–4.609	0.000

Abbreviations: LM liver metastases, RAS rat sarcoma viral oncogene homolog, CEA carcinoembryonic antigen, CA19-9 carbohydrate antigen 19-9

ISSN: 1477-7819