Table 5 Univariate and multivariate logistic regression analyses of irAEs

Sex

0.330

0.646

0.268–1.555

—

—

—

Age

0.975

1.001

0.957–1.046

—

—

—

ECOG

0.0499*

0.507

0.241–1.065

0.046*

0.159

0.026–0.970

 0–1 ^c

 2

Tumor type

0.795

1.018

0.892–1.161

0.770

—

—

TNM clinical classification

0.508

0.786

0.385–1.605

—

—

—

Treatment line

0.150

1.939

0.787–4.777

0.69

2.908

0.922–9.169

 First-line and second-line ^c

 Third-line and above

Treatment

0.125

0.780

0.567–1.072

0.044*

—

—

 Immunotherapy ^c

Base

—

—

 Immunotherapy + targeted therapy

0.005*

0.156

0.045–0.544

 Immunotherapy + chemotherapy

0.301

0.550

0.178–1.706

 Immunotherapy + chemotherapy + targeted therapy

0.383

0.363

0.037–3.533

NLR

0.0499*

0.196

0.038–1.000

0.505

0.501

0.066–3.816

 Low (≤ 8.58) ^c

 High (> 8.58)

PLR

0.091

0.492

0.216–1.120

0.216

0.537

0.200–1.440

 Low (< 180.68) ^c

 High (≥ 180.68)

AEC

0.012*

3.651

1.322–10.076

0.014*

4.114

1.32–12.858

 Low (≤ 0.045 × 10⁹/L) ^c

 High (> 0.045 × 10⁹/L)