Table 2 Univariate analysis for the prognosis of patients with advanced gastrointestinal cancers
Variables | PFS | OS | ||
|---|---|---|---|---|
Univariate analysis | Univariate analysis | |||
HR (95% CI) | P value | HR (95% CI) | P values | |
Age, years | ||||
 < 69 vs ≥ 69 | 0.53 (0.25–1.16) | P = 0.11 | 0.61 (0.31–1.20) | P = 0.08 |
Sex | ||||
 Female vs male | 0.58 (0.28–1.21) | P = 0.15 | 0.76 (0.43–1.35) | P = 0.36 |
CEA | ||||
 Normal vs abnormal | 0.98 (0.48–1.97) | P = 0.95 | 0.98 (0.57–1.67) | P = 0.93 |
CA199 | ||||
 Normal vs abnormal | 0.51 (0.25–1.01) | P = 0.06 | 0.63 (0.37–1.09) | P = 0.41 |
Grade | ||||
 G1–2 vs G3 | 0.76 (0.37–1.57) | P = 0.47 | 0.77 (0.43–1.36) | P = 0.37 |
Lymph node metastasis | ||||
 No vs yes | 0.54 (0.27–1.10) | P = 0.07 | 0.81 (0.47–1.37) | P = 0.40 |
Visceral metastasis | ||||
 No vs yes | 0.84 (0.38–1.86) | P = 0.64 | 0.96 (0.51–1.80) | P = 0.90 |
CD3 + cell | ||||
 High vs low | 0.40 (0.13–1.27) | P = 0.023 | 0.36 (0.09–1.52) | P = 0.02 |
CD4 + cell | ||||
High vs low | 0.41 (0.17–0.97) | P = 0.01 | 0.40 (0.14–0.10) | P = 0.07 |
CD8 + cell | ||||
 High vs low | 0.47 (0.20–1.11) | P = 0.03 | 0.44 (0.19–0.99) | P = 0.006 |
NK cell | ||||
 High vs low | 1.92 (0.93–3.96) | P = 0.053 | 1.53 (0.86–2.70) | P = 0.11 |
CD4 + CD25+CD127low | ||||
 High vs low | 2.75 (1.33–5.69) | P = 0.027 | 1.87 (1.10–3.20) | P = 0.02 |
cIS1 | ||||
 High vs low | 0.34 (0.14–0.80) | P = 0.001 | 0.36 (0.16–0.84) | P = 0.0004 |
cIS2 | ||||
 High vs low | 0.26 (0.11–0.59) | P < 0.0001 | 0.26 (0.10–0.66) | P < 0.0001 |