Fig. 1

RNF180 was downregulated in non-small cell lung cancer (NSCLC) and positively correlated with its overall survival rate. A RNF180 expression in patients with lung adenocarcinoma (LUAD) (n = 526) and healthy individuals (n = 59) was analyzed based on the TCGA database. *** p<0.001 vs para-cancerous. B Survival probability of patients with LUAD exhibiting high RNF180 expression (n = 120) and low-to-medium RNF180 expression (n = 119) was analyzed using the Kaplan–Meier method. C RNF180 mRNA levels in 30 pairs of tumorous and adjacent normal tissues were measured using qRT-PCR. *** p<0.001 vs para-cancerous. D Representative IHC image of RNF180 expression in tissues of healthy controls (n = 5) and patients with NSCLC (n = 93) was assessed using the IHC assay (original magnification 200×). Representative IHC image is presented. E Overall survival probability of patients with NSCLC was analyzed using the Kaplan–Meier method and compared between high RNF180-expressed (n = 53) and low RNF180-expressed (n = 40) groups