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Table 3 Univariate and multivariate Cox regression analyses of prognostic factors in propensity-matched patients

From: Prognostic significance of 4R lymph node dissection in patients with right primary non-small cell lung cancer

Variables

DFS

OS

Univariate analyses

Multivariate analyses

Univariate analyses

Multivariate analyses

HR

95% CI

P

HR

95% CI

P

HR

95% CI

P

HR

95% CI

P

Age (year)

 < 65

1

     

1

     

 ≥ 65

0.93

0.77–1.13

0.465

   

0.98

0.80–1.20

0.847

   

Gender

 Female

1

     

1

     

 Male

1.09

0.91–1.30

0.309

   

1.15

0.96–1.39

0.131

   

Smoking history

 No

1

     

1

     

 Yes

1.02

0.86–1.22

0.792

   

1.07

0.89–1.28

0.496

   

Surgical approaches

 Thoracoscopic surgery

1

     

1

     

 Thoracotomy

1.084

0.91–1.29

0.366

   

1.15

0.95–1.39

0.146

   

Tumor location

 Upper lobe

1

     

1

     

 Middle lobe

0.99

0.74–1.33

0.952

   

1.09

0.79–1.48

0.607

   

 Lower lobe

1.06

0.88–1.28

0.514

   

1.12

0.92–1.36

0.270

   

Histological type

 Adenocarcinoma

1

     

1

     

 Squamous cell carcinoma

0.79

0.61–1.03

0.085

   

0.83

0.63–1.09

0.182

   

 Others

1.00

0.72–1.38

0.992

   

1.06

0.76–1.49

0.719

   

Adjuvant chemotherapy

 No

1

     

1

     

 Yes

0.97

0,81–1.17

0.75

   

1.01

0.83–1.23

0.926

   

pT stage

 T1a

1

  

1

  

1

  

1

  

 T1b

0.90

0.65–1.26

0.569

0.92

0.66–1.28

0.631

0.98

0.68–1.40

0.917

0.98

0.68–1.42

0.950

 T1c

1.23

0.89–1.70

0.191

1.16

0.84–1.61

0.341

1.29

0.90–1.84

0.152

1.20

0.84–1.72

0.307

 T2a

1.27

0.89–1.82

0.184

0.91

0.48–1.73

0.795

1.46

0.99–2.15

0.055

1.05

0.55–2.03

0.862

 T2b

1.49

0.98–2.28

0.061

1.13

0.60–2.13

0.684

1.73

1.10–2.71

0.017

1.21

0.62–2.35

0.571

 T3

1.23

0.81–1.88

0.322

1.43

0.47–4.31

0.521

1.44

0.91–2.26

0.110

1.81

0.56–5.75

0.315

 T4

1.96

1.25–3.09

0.003

1.44

0.33–6.31

0.622

2.13

1.31–3.48

0.002

1.84

0.40–8.42

0.428

pN stage

 N0

1

  

1

  

1

  

1

  

 N1

1.70

1.19–2.42

0.003

2.16

0.86–5.39

0.097

1.83

1.27–2.63

0.001

2.55

0.98–6.66

0.054

 N2

1.83

1.48–2.27

< 0.001

1.65

0.29–9.24

0.568

1.93

1.54–2.42

< 0.001

2.25

0.36–13.91

0.382

Station 4R LN dissection

 Yes

1

  

1

  

1

  

1

  

 No

1.31

1.06–1.61

0.009

1.33

1.08–1.64

0.007

1.28

1.03–1.60

0.025

1.31

1.04–1.63

0.018

pTNM stage

 IA

1

  

1

  

1

  

1

  

 IB

1.33

1.01–1.76

0.044

1.48

0.78–2.81

0.228

1.45

1.08–1.95

0.013

1.46

0.76–2.81

0.251

 IIA

1.46

0.96–2.22

0.074

1.29

0.63–2.62

0.474

1.66

1.08–2.56

0.021

1.44

0.69–3.00

0.327

 IIB

1.27

0.94–1.72

0.116

0.76

0.28–2.07

0.595

1.41

1.02–1.93

0.034

0.69

0.24–1.99

0.502

 IIIA

1.87

1.49–2.35

<0.001

1.09

0.19–6.09

0.913

2.00

1.57–2.54

<0.001

0.85

0.13–5.21

0.863

 IIIB

2.78

1.78–4.35

<0.001

1.24

0.06–23.72

0.884

3.07

1.96–4.82

<0.001

0.82

0.03–18.11

0.902