Variables | DFS | OS | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Univariate analyses | Multivariate analyses | Univariate analyses | Multivariate analyses | |||||||||
HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | |
Age (year) | ||||||||||||
 < 65 | 1 |  |  |  |  |  | 1 |  |  |  |  |  |
 ≥ 65 | 0.93 | 0.77–1.13 | 0.465 |  |  |  | 0.98 | 0.80–1.20 | 0.847 |  |  |  |
Gender | ||||||||||||
 Female | 1 |  |  |  |  |  | 1 |  |  |  |  |  |
 Male | 1.09 | 0.91–1.30 | 0.309 |  |  |  | 1.15 | 0.96–1.39 | 0.131 |  |  |  |
Smoking history | ||||||||||||
 No | 1 |  |  |  |  |  | 1 |  |  |  |  |  |
 Yes | 1.02 | 0.86–1.22 | 0.792 |  |  |  | 1.07 | 0.89–1.28 | 0.496 |  |  |  |
Surgical approaches | ||||||||||||
 Thoracoscopic surgery | 1 |  |  |  |  |  | 1 |  |  |  |  |  |
 Thoracotomy | 1.084 | 0.91–1.29 | 0.366 |  |  |  | 1.15 | 0.95–1.39 | 0.146 |  |  |  |
Tumor location | ||||||||||||
 Upper lobe | 1 |  |  |  |  |  | 1 |  |  |  |  |  |
 Middle lobe | 0.99 | 0.74–1.33 | 0.952 |  |  |  | 1.09 | 0.79–1.48 | 0.607 |  |  |  |
 Lower lobe | 1.06 | 0.88–1.28 | 0.514 |  |  |  | 1.12 | 0.92–1.36 | 0.270 |  |  |  |
Histological type | ||||||||||||
 Adenocarcinoma | 1 |  |  |  |  |  | 1 |  |  |  |  |  |
 Squamous cell carcinoma | 0.79 | 0.61–1.03 | 0.085 |  |  |  | 0.83 | 0.63–1.09 | 0.182 |  |  |  |
 Others | 1.00 | 0.72–1.38 | 0.992 |  |  |  | 1.06 | 0.76–1.49 | 0.719 |  |  |  |
Adjuvant chemotherapy | ||||||||||||
 No | 1 |  |  |  |  |  | 1 |  |  |  |  |  |
 Yes | 0.97 | 0,81–1.17 | 0.75 |  |  |  | 1.01 | 0.83–1.23 | 0.926 |  |  |  |
pT stage | ||||||||||||
 T1a | 1 |  |  | 1 |  |  | 1 |  |  | 1 |  |  |
 T1b | 0.90 | 0.65–1.26 | 0.569 | 0.92 | 0.66–1.28 | 0.631 | 0.98 | 0.68–1.40 | 0.917 | 0.98 | 0.68–1.42 | 0.950 |
 T1c | 1.23 | 0.89–1.70 | 0.191 | 1.16 | 0.84–1.61 | 0.341 | 1.29 | 0.90–1.84 | 0.152 | 1.20 | 0.84–1.72 | 0.307 |
 T2a | 1.27 | 0.89–1.82 | 0.184 | 0.91 | 0.48–1.73 | 0.795 | 1.46 | 0.99–2.15 | 0.055 | 1.05 | 0.55–2.03 | 0.862 |
 T2b | 1.49 | 0.98–2.28 | 0.061 | 1.13 | 0.60–2.13 | 0.684 | 1.73 | 1.10–2.71 | 0.017 | 1.21 | 0.62–2.35 | 0.571 |
 T3 | 1.23 | 0.81–1.88 | 0.322 | 1.43 | 0.47–4.31 | 0.521 | 1.44 | 0.91–2.26 | 0.110 | 1.81 | 0.56–5.75 | 0.315 |
 T4 | 1.96 | 1.25–3.09 | 0.003 | 1.44 | 0.33–6.31 | 0.622 | 2.13 | 1.31–3.48 | 0.002 | 1.84 | 0.40–8.42 | 0.428 |
pN stage | ||||||||||||
 N0 | 1 |  |  | 1 |  |  | 1 |  |  | 1 |  |  |
 N1 | 1.70 | 1.19–2.42 | 0.003 | 2.16 | 0.86–5.39 | 0.097 | 1.83 | 1.27–2.63 | 0.001 | 2.55 | 0.98–6.66 | 0.054 |
 N2 | 1.83 | 1.48–2.27 | < 0.001 | 1.65 | 0.29–9.24 | 0.568 | 1.93 | 1.54–2.42 | < 0.001 | 2.25 | 0.36–13.91 | 0.382 |
Station 4R LN dissection | ||||||||||||
 Yes | 1 |  |  | 1 |  |  | 1 |  |  | 1 |  |  |
 No | 1.31 | 1.06–1.61 | 0.009 | 1.33 | 1.08–1.64 | 0.007 | 1.28 | 1.03–1.60 | 0.025 | 1.31 | 1.04–1.63 | 0.018 |
pTNM stage | ||||||||||||
 IA | 1 |  |  | 1 |  |  | 1 |  |  | 1 |  |  |
 IB | 1.33 | 1.01–1.76 | 0.044 | 1.48 | 0.78–2.81 | 0.228 | 1.45 | 1.08–1.95 | 0.013 | 1.46 | 0.76–2.81 | 0.251 |
 IIA | 1.46 | 0.96–2.22 | 0.074 | 1.29 | 0.63–2.62 | 0.474 | 1.66 | 1.08–2.56 | 0.021 | 1.44 | 0.69–3.00 | 0.327 |
 IIB | 1.27 | 0.94–1.72 | 0.116 | 0.76 | 0.28–2.07 | 0.595 | 1.41 | 1.02–1.93 | 0.034 | 0.69 | 0.24–1.99 | 0.502 |
 IIIA | 1.87 | 1.49–2.35 | <0.001 | 1.09 | 0.19–6.09 | 0.913 | 2.00 | 1.57–2.54 | <0.001 | 0.85 | 0.13–5.21 | 0.863 |
 IIIB | 2.78 | 1.78–4.35 | <0.001 | 1.24 | 0.06–23.72 | 0.884 | 3.07 | 1.96–4.82 | <0.001 | 0.82 | 0.03–18.11 | 0.902 |