Table 4 Association between polymorphism of GSTP1 genes and toxicities of chemotherapy
Toxicities | A/A (n = 94) | A/G (n = 45) | G/G (n = 3) | A/G + G/G (n = 48) |
|---|---|---|---|---|
Hematological toxicity | ||||
Leucopenia | ||||
No toxicities | 10(10.6%) | 4(8.9%) | 0(0) | 4(8.3%) |
Grade I/II | 40(42.6%) | 16(35.6%) | 1(33.3%) | 17(35.4%) |
Grade III/IV | 44(46.8%) | 25(55.6%) | 2(66.7%) | 27(56.3%) |
P value* | 0.652 | 1.000 | 0.574 | |
Neutropenia | ||||
No toxicities | 21(22.3%) | 3(6.7%) | 0(0) | 3(6.3%) |
Grade I/II | 41(43.6%) | 25(55.6%) | 3(100.0%) | 28(58.3%) |
Grade III/IV | 32(34.0%) | 17(37.8%) | 0(0) | 17(35.4%) |
P value* | 0.050 | 0.311 | 0.035 | |
Anemia | ||||
No toxicities | 30(31.9%) | 12(26.7%) | 2(66.7%) | 14(29.2%) |
Grade I/II | 57(60.6%) | 29(64.4%) | 1(33.3%) | 30(62.5%) |
Grade III/IV | 7(7.4%) | 4(8.9%) | 0(0) | 4(8.3%) |
P value* | 0.810 | 0.432 | 0.961 | |
Thrombocytopenia | ||||
No toxicities | 56(59.6%) | 19(42.2%) | 3(100.0%) | 22(45.8%) |
Grade I/II | 21(22.3%) | 16(35.6%) | 0(0) | 16(33.3%) |
Grade III/IV | 17(18.1%) | 10(22.2%) | 0(0) | 10(20.8%) |
P value* | 0.145 | 0.756 | 0.265 | |
Hepatic function | ||||
No toxicities | 47(50.0%) | 20(44.4%) | 1(33.3%) | 21(43.8%) |
Grade I/II | 46(48.9%) | 23(51.1%) | 2(66.7%) | 25(52.1%) |
Grade III/IV | 1(1.1%) | 2(4.4%) | 0(0) | 2(4.2%) |
P value* | 0.386 | 1.000 | 0.402 | |
Renal function | ||||
No toxicities | 91(96.8%) | 43(95.6%) | 3(100.0%) | 46(95.8%) |
Grade I/II | 3(3.2%) | 2(4.4%) | 0(0) | 2(4.2%) |
Grade III/IV | 0(0) | 0(0) | 0(0) | 0(0) |
P value# | 0.659 | 1.000 | 1.000 | |
Cardiac function | ||||
No toxicities | 93(98.9%) | 45(100.0%) | 3(100.0%) | 48(100.0%) |
Grade I/II | 1(1.1%) | 0(0) | 0(0) | 0(0) |
Grade III/IV | 0(0) | 0(0) | 0(0) | 0(0) |
P value# | 1.000 | 1.000 | 1.000 | |
Gastrointestinal toxicity | ||||
Vomiting | ||||
No toxicities | 13(13.8%) | 6(13.3%) | 0(0) | 6(12.5%) |
Grade I/II | 81(86.2%) | 39(86.7%) | 3(100.0%) | 42(87.5%) |
Grade III/IV | 0(0) | 0(0) | 0(0) | 0(0) |
P value# | 1.000 | 1.000 | 1.000 | |
Diarrhea | ||||
No toxicities | 92(97.9%) | 43(95.6%) | 2(66.7%) | 45(93.8%) |
Grade I/II | 2(2.1%) | 2(4.4%) | 1(33.3%) | 3(6.2%) |
Grade III/IV | 0(0) | 0(0) | 0(0) | 0(0) |
P value# | 0.595 | 0.091 | 0.336 | |
Hair loss | ||||
No toxicities | 0(0) | 0(0) | 0(0) | 0(0) |
Grade I/II | 94(100.0%) | 45(100.0%) | 3(100.0%) | 48(100.0%) |
Grade III/IV | 0(0) | 0(0) | 0(0) | 0(0) |
P value# | - | - | - | |
Numbness of hands and feet | ||||
No toxicities | 34(36.2%) | 16(35.6%) | 1(33.3%) | 17(35.4%) |
Grade I/II | 60(63.8%) | 29(64.4%) | 2(66.7%) | 31(64.6%) |
Grade III/IV | 0(0) | 0(0) | 0(0) | 0(0) |
P value# | 1.000 | 1.000 | 1.000 | |