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Table 4 Association between polymorphism of GSTP1 genes and toxicities of chemotherapy

From: GSTP1 c.313A > G mutation is an independent risk factor for neutropenia hematotoxicity induced by anthracycline-/paclitaxel-based chemotherapy in breast cancer patients

Toxicities A/A (n = 94) A/G (n = 45) G/G (n = 3) A/G + G/G (n = 48)
Hematological toxicity
 Leucopenia
  No toxicities 10(10.6%) 4(8.9%) 0(0) 4(8.3%)
  Grade I/II 40(42.6%) 16(35.6%) 1(33.3%) 17(35.4%)
  Grade III/IV 44(46.8%) 25(55.6%) 2(66.7%) 27(56.3%)
  P value*   0.652 1.000 0.574
 Neutropenia
  No toxicities 21(22.3%) 3(6.7%) 0(0) 3(6.3%)
  Grade I/II 41(43.6%) 25(55.6%) 3(100.0%) 28(58.3%)
  Grade III/IV 32(34.0%) 17(37.8%) 0(0) 17(35.4%)
  P value*   0.050 0.311 0.035
 Anemia
  No toxicities 30(31.9%) 12(26.7%) 2(66.7%) 14(29.2%)
  Grade I/II 57(60.6%) 29(64.4%) 1(33.3%) 30(62.5%)
  Grade III/IV 7(7.4%) 4(8.9%) 0(0) 4(8.3%)
  P value*   0.810 0.432 0.961
 Thrombocytopenia
  No toxicities 56(59.6%) 19(42.2%) 3(100.0%) 22(45.8%)
  Grade I/II 21(22.3%) 16(35.6%) 0(0) 16(33.3%)
  Grade III/IV 17(18.1%) 10(22.2%) 0(0) 10(20.8%)
  P value*   0.145 0.756 0.265
 Hepatic function
  No toxicities 47(50.0%) 20(44.4%) 1(33.3%) 21(43.8%)
  Grade I/II 46(48.9%) 23(51.1%) 2(66.7%) 25(52.1%)
  Grade III/IV 1(1.1%) 2(4.4%) 0(0) 2(4.2%)
  P value*   0.386 1.000 0.402
 Renal function
  No toxicities 91(96.8%) 43(95.6%) 3(100.0%) 46(95.8%)
  Grade I/II 3(3.2%) 2(4.4%) 0(0) 2(4.2%)
  Grade III/IV 0(0) 0(0) 0(0) 0(0)
  P value#   0.659 1.000 1.000
 Cardiac function
  No toxicities 93(98.9%) 45(100.0%) 3(100.0%) 48(100.0%)
  Grade I/II 1(1.1%) 0(0) 0(0) 0(0)
  Grade III/IV 0(0) 0(0) 0(0) 0(0)
  P value#   1.000 1.000 1.000
Gastrointestinal toxicity
 Vomiting
  No toxicities 13(13.8%) 6(13.3%) 0(0) 6(12.5%)
  Grade I/II 81(86.2%) 39(86.7%) 3(100.0%) 42(87.5%)
  Grade III/IV 0(0) 0(0) 0(0) 0(0)
  P value#   1.000 1.000 1.000
 Diarrhea
  No toxicities 92(97.9%) 43(95.6%) 2(66.7%) 45(93.8%)
  Grade I/II 2(2.1%) 2(4.4%) 1(33.3%) 3(6.2%)
  Grade III/IV 0(0) 0(0) 0(0) 0(0)
  P value#   0.595 0.091 0.336
 Hair loss
  No toxicities 0(0) 0(0) 0(0) 0(0)
  Grade I/II 94(100.0%) 45(100.0%) 3(100.0%) 48(100.0%)
  Grade III/IV 0(0) 0(0) 0(0) 0(0)
  P value#   - - -
 Numbness of hands and feet
  No toxicities 34(36.2%) 16(35.6%) 1(33.3%) 17(35.4%)
  Grade I/II 60(63.8%) 29(64.4%) 2(66.7%) 31(64.6%)
  Grade III/IV 0(0) 0(0) 0(0) 0(0)
  P value#   1.000 1.000 1.000
  1. *Whether toxicities and the grade of toxicities in patients with mutant genotype vs. wild-type, respectively
  2. #Toxicities or no in patients with mutant genotype vs. wild-type, respectively