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Table 3 Frequency of all grade toxicities in patients

From: GSTP1 c.313A > G mutation is an independent risk factor for neutropenia hematotoxicity induced by anthracycline-/paclitaxel-based chemotherapy in breast cancer patients

Toxicities Total (n = 142) GSTP1 c.313A > G wild-type (n = 94) GSTP1 c.313A > G mutation (n = 48)
Grades I/II Grades III/IV Grades I/II Grades III/IV Grades I/II Grades III/IV
Hematological toxicity
 Leucopenia 57 (40.1%) 71 (50.0%) 40 (42.6%) 44 (46.8%) 17 (35.4%) 27 (56.3%)
 Neutropenia 69 (48.6%) 49 (34.5%) 41 (43.6%) 32 (34.0%) 28 (58.3%) 17 (35.4%)
 Anemia 87 (61.3%) 11 (7.7%) 57 (60.6%) 7 (7.4%) 30 (62.5%) 4 (8.3%)
 Thrombocytopenia 37 (26.1%) 27 (19.0%) 21 (22.3%) 17 (18.1%) 16 (33.3%) 10 (20.8%)
Hepatic function 71 (50.0%) 3 (2.1%) 46 (48.9%) 1 (1.1%) 25 (52.1%) 2 (4.2%)
Renal function 5 (3.5%) 0 (0) 3 (3.2%) 0 (0) 2 (4.2%) 0 (0)
Cardiac function 1 (0.7%) 0 (0) 1 (1.1%) 0 (0) 0 (0) 0 (0)
Gastrointestinal toxicity
 Vomiting 123 (86.6%) 0 (0) 81 (86.2%) 0 (0) 42 (87.5%) 0 (0)
 Diarrhea 5 (3.5%) 0 (0) 2 (2.1%) 0 (0) 3 (6.3%) 0 (0)
Hair loss 142 (100.0%) 0 (0) 94 (100.0%) 0 (0) 48 (100.0%) 0 (0)
Numbness of hands and feet 91 (64.1%) 0 (0) 60 (63.8%) 0 (0) 31 (64.6%) 0 (0)