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Table 3 Frequency of all grade toxicities in patients

From: GSTP1 c.313A > G mutation is an independent risk factor for neutropenia hematotoxicity induced by anthracycline-/paclitaxel-based chemotherapy in breast cancer patients

Toxicities

Total (n = 142)

GSTP1 c.313A > G wild-type (n = 94)

GSTP1 c.313A > G mutation (n = 48)

Grades I/II

Grades III/IV

Grades I/II

Grades III/IV

Grades I/II

Grades III/IV

Hematological toxicity

 Leucopenia

57 (40.1%)

71 (50.0%)

40 (42.6%)

44 (46.8%)

17 (35.4%)

27 (56.3%)

 Neutropenia

69 (48.6%)

49 (34.5%)

41 (43.6%)

32 (34.0%)

28 (58.3%)

17 (35.4%)

 Anemia

87 (61.3%)

11 (7.7%)

57 (60.6%)

7 (7.4%)

30 (62.5%)

4 (8.3%)

 Thrombocytopenia

37 (26.1%)

27 (19.0%)

21 (22.3%)

17 (18.1%)

16 (33.3%)

10 (20.8%)

Hepatic function

71 (50.0%)

3 (2.1%)

46 (48.9%)

1 (1.1%)

25 (52.1%)

2 (4.2%)

Renal function

5 (3.5%)

0 (0)

3 (3.2%)

0 (0)

2 (4.2%)

0 (0)

Cardiac function

1 (0.7%)

0 (0)

1 (1.1%)

0 (0)

0 (0)

0 (0)

Gastrointestinal toxicity

 Vomiting

123 (86.6%)

0 (0)

81 (86.2%)

0 (0)

42 (87.5%)

0 (0)

 Diarrhea

5 (3.5%)

0 (0)

2 (2.1%)

0 (0)

3 (6.3%)

0 (0)

Hair loss

142 (100.0%)

0 (0)

94 (100.0%)

0 (0)

48 (100.0%)

0 (0)

Numbness of hands and feet

91 (64.1%)

0 (0)

60 (63.8%)

0 (0)

31 (64.6%)

0 (0)