Toxicities | Total (n = 142) | GSTP1 c.313A > G wild-type (n = 94) | GSTP1 c.313A > G mutation (n = 48) | |||
---|---|---|---|---|---|---|
Grades I/II | Grades III/IV | Grades I/II | Grades III/IV | Grades I/II | Grades III/IV | |
Hematological toxicity | ||||||
Leucopenia | 57 (40.1%) | 71 (50.0%) | 40 (42.6%) | 44 (46.8%) | 17 (35.4%) | 27 (56.3%) |
Neutropenia | 69 (48.6%) | 49 (34.5%) | 41 (43.6%) | 32 (34.0%) | 28 (58.3%) | 17 (35.4%) |
Anemia | 87 (61.3%) | 11 (7.7%) | 57 (60.6%) | 7 (7.4%) | 30 (62.5%) | 4 (8.3%) |
Thrombocytopenia | 37 (26.1%) | 27 (19.0%) | 21 (22.3%) | 17 (18.1%) | 16 (33.3%) | 10 (20.8%) |
Hepatic function | 71 (50.0%) | 3 (2.1%) | 46 (48.9%) | 1 (1.1%) | 25 (52.1%) | 2 (4.2%) |
Renal function | 5 (3.5%) | 0 (0) | 3 (3.2%) | 0 (0) | 2 (4.2%) | 0 (0) |
Cardiac function | 1 (0.7%) | 0 (0) | 1 (1.1%) | 0 (0) | 0 (0) | 0 (0) |
Gastrointestinal toxicity | ||||||
Vomiting | 123 (86.6%) | 0 (0) | 81 (86.2%) | 0 (0) | 42 (87.5%) | 0 (0) |
Diarrhea | 5 (3.5%) | 0 (0) | 2 (2.1%) | 0 (0) | 3 (6.3%) | 0 (0) |
Hair loss | 142 (100.0%) | 0 (0) | 94 (100.0%) | 0 (0) | 48 (100.0%) | 0 (0) |
Numbness of hands and feet | 91 (64.1%) | 0 (0) | 60 (63.8%) | 0 (0) | 31 (64.6%) | 0 (0) |