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Table 3 Univariate and multivariate analyses for the performance of axillary lymph node dissection in 7478 Korean patients who met the Z0011 criteria

From: Impact of the ACOSOG Z0011 trial on surgical practice in Asian patients: trends in axillary surgery for breast cancer from a Korean Breast Cancer Registry analysis

Variables

Univariate analysis

Multivariate analysisa

Unadjusted OR

95% CI

p value

Adjusted OR

95% CI

p value

Age at surgery

  < 40

Ref

     

 40–49

1.072

0.908–1.267

0.410

   

 50–59

1.071

0.905–1.268

0.423

   

 60–69

1.078

0.888–1.309

0.446

   

 70–79

0.987

0.761–1.279

0.920

   

  > 80

0.743

0.413–1.340

0.324

   

pT

 pT1

Ref

  

Ref

  

 pT2

1.604

1.455–1.767

 < 0.0001

1.458

1.294–1.642

 < 0.0001*

Multifocality

 Single lesion

Ref

     

 Multifocal lesion

1.184

0.972–1.442

0.094

   

Histologic subtype

 IDC

1.173

1.035–1.330

0.013

1.279

0.992–1.649

0.058

 Others

Ref

  

Ref

  

Histologic grade

 I

Ref

  

Ref

  

 II

0.856

0.736–0.997

0.046

0.715

0.599–0.852

 < 0.001*

 III

1.177

0.998–1.389

0.053

0.872

0.707–1.076

0.202

Lymphatic invasion

 No

Ref

  

Ref

  

 Yes

1.549

1.388–1.728

 < 0.0001

1.519

1.351–1.709

 < 0.0001*

ER/HER2 status

 ER + /HER2-

Ref

  

Ref

  

 HER2 + 

1.353

1.170–1.564

 < 0.0001

1.263

1.066–1.497

0.007*

 ER-/HER2-

1.336

1.129–1.582

0.001

1.246

1.015–1.529

0.036*

  1. pT Pathologic tumor stage, IDC Invasive ductal carcinoma, ER Estrogen receptor, HER2, human epidermal growth factor receptor 2, OR Odds ratio, CI Confidence interval
  2. aAdjusted for pathologic tumor stage, histologic subtype, histologic grade, lymphatic invasion, and ER/HER2 status
  3. *P value < 0.05
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World Journal of Surgical Oncology

ISSN: 1477-7819

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