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Table 3 Univariate and multivariate analyses for the performance of axillary lymph node dissection in 7478 Korean patients who met the Z0011 criteria

From: Impact of the ACOSOG Z0011 trial on surgical practice in Asian patients: trends in axillary surgery for breast cancer from a Korean Breast Cancer Registry analysis

Variables Univariate analysis Multivariate analysisa
Unadjusted OR 95% CI p value Adjusted OR 95% CI p value
Age at surgery
  < 40 Ref      
 40–49 1.072 0.908–1.267 0.410    
 50–59 1.071 0.905–1.268 0.423    
 60–69 1.078 0.888–1.309 0.446    
 70–79 0.987 0.761–1.279 0.920    
  > 80 0.743 0.413–1.340 0.324    
pT
 pT1 Ref    Ref   
 pT2 1.604 1.455–1.767  < 0.0001 1.458 1.294–1.642  < 0.0001*
Multifocality
 Single lesion Ref      
 Multifocal lesion 1.184 0.972–1.442 0.094    
Histologic subtype
 IDC 1.173 1.035–1.330 0.013 1.279 0.992–1.649 0.058
 Others Ref    Ref   
Histologic grade
 I Ref    Ref   
 II 0.856 0.736–0.997 0.046 0.715 0.599–0.852  < 0.001*
 III 1.177 0.998–1.389 0.053 0.872 0.707–1.076 0.202
Lymphatic invasion
 No Ref    Ref   
 Yes 1.549 1.388–1.728  < 0.0001 1.519 1.351–1.709  < 0.0001*
ER/HER2 status
 ER + /HER2- Ref    Ref   
 HER2 +  1.353 1.170–1.564  < 0.0001 1.263 1.066–1.497 0.007*
 ER-/HER2- 1.336 1.129–1.582 0.001 1.246 1.015–1.529 0.036*
  1. pT Pathologic tumor stage, IDC Invasive ductal carcinoma, ER Estrogen receptor, HER2, human epidermal growth factor receptor 2, OR Odds ratio, CI Confidence interval
  2. aAdjusted for pathologic tumor stage, histologic subtype, histologic grade, lymphatic invasion, and ER/HER2 status
  3. *P value < 0.05