Table 2 Detailed data of mNMIBC cases from identified studies (see supplementary material) and our center

1

Seymour, 1972

33

M

> 3

1

G2

0

117

Lung

ROM

NED after 1 year

2

Matthews, 1984

35

F

/

≥ 2

T1G2

≥ 2

86

Bone

/

DOD after 6 months

3

Matthews, 1984

48

F

/

≥ 2

TaG1

≥ 2

100

Lung

/

/

4

Matthews, 1984

76

M

/

1

TaG2

2

14

Bone

/

DOD after 1 months

5

Matthews, 1984

73

M

/

2

T1G2

0

25

Lung

/

DOD after 1 months

6

Matthews, 1984

57

M

/

≥ 2

T1G3

≥ 2

70

Liver

/

DOD after 2 months

7

Matthews, 1984

77

M

/

≥ 2

T1G2

0

12

Lung

/

/

8

Andriole, 1985

60

F

/

/

T1G1

5

31

Ovary, tube, uterus

ROM, CT

Local progression after 31 months

9

Francis, 1992

70

F

/

/

TaG1

≥ 2

84

Ovary

ROM

/

10

Kakehi, 1992

63

M

> 3

> 5

TaG2

5

46

Lung

/

/

11

Kakehi, 1992

55

M

< 1

2

T1G2

0

26

Inguinal LN

/

/

12

Kakehi, 1992

48

M

> 3

> 5

T1G3

3

12

Inguinal LN

/

/

13

Kakehi, 1992

51

M

1–3

> 5

TaG2

5

38

Lung

ROM

/

14

Kawashima, 1993

67

M

> 3

≥ 2

T1G3

2

/

Bone

/

DOD

15

Koh, 1994

33

M

/

/

TaG1

≥ 1

108

Lung

CT, ROM

NED after 14 months

16

Kardar, 1998

60

F

/

/

TaG2

3

48

Ovary

ROM

DOD after 3 months

17

Saito, 1999

79

M

/

/

T1G2

0

18

Skin

ROM, CT

NED after 15 months

18

Davies, 2003

56

M

2

1

T1HG, p63(+)

/

0

Brain

ROM RT, CT

/

19

Shikishima, 2006

71

M

/

/

T1G2

2

36

Orbit, bone

RT, CT

DOD after 7 months

20

Hirayama, 2007

64

F

4

≥ 2

T1G1

4

30

Lung

ROM, IVC

NED after 6 years

21

Murakami, 2007

76

F

4

1

T1G3

0

23

Uterus

RT

PR after 4 months

22

Haga, 2008

95

M

/

/

T1G3

1

9

Lung

None

DOD after 1 months

23

Zennami, 2008

65

M

2

2

T1G3, CIS, HER-2(+)

0

34

Brain

ROM

DOD after 2.5 months

24

Dougherty, 2009

66

M

/

/

LG

≥ 2

120

Lung

ROM, CT

NED after 1 year

25

Blasberg, 2009

83

F

/

/

T1HG, sarcomatoid

0

3

Colon

ROM

/

26

D’Souza, 2011

69

F

2

1

T1G3, LVI(+)

0

10

Cerebellum

RT

NED after 21 months

27

Arai, 2012

52

F

3

1

T1G3

2

19

Lung

CT, ROM

NED after 53 months

28

Canter, 2012

76

F

3

1

T1HG, CIS, micropapillary

/

0

Pancreas

CT

/

29

Madan, 2012

85

M

/

/

LG

1

12

Lung

RT

/

30

Sasaki, 2013

66

M

3.8

3

T1HG, CIS

1

10

Bone

CT

PR after 6 months

31

Sano, 2013

60

M

< 1

/

TaLG

6

60

Lung

ROM, CT

NED after 30 months

32

Zalawadia, 2014

65

F

/

/

T1

0

60

Liver

None

DOD within 1 week

33

Hong, 2015

60

M

4.5

1

T1HG, ki67(70%+), p53(70%+), EGFR(+)

0

3

Bone

CT

DOD after 4 months

34

Vural, 2015

53

M

/

1

TaLG

3

96

Lung

CT, ROM

/

35

Kelten, 2015

75

M

3

1

T1HG, CIS

0

15

Cerebellum

ROM, RT

DOD after 2 months

36

Teyssonneau, 2017

60

M

/

/

T1HG

0

36

Meninges, bone

CT

NED after 4 years

37

Kida, 2018

77

M

2

1

T1HG, LVI (+)

0

10

Bone, liver

RT

DOD after 5 months

38

Kida, 2018

70

M

2

1

T1HG

0

18

Retroperitoneal LN

ROM, CT

NED after 1 year

39

Frydenlund, 2018

52

M

3

3

TaHG

0

30

Bone

RT, CT

/

40

Juri, 2018

63

M

/

/

CIS, HG

0

60

Cervical LN

/

/

41

Juri, 2018

79

M

/

/

CIS, HG

3

63

Mediastinal LN, bone

/

/

42

Rodríguez-López, 2018

58

M

/

/

TaLG

6

> 60

Lung

ROM, CT

NED after 3 years

43

Garrido-Abad, 2019

67

M

/

/

TaLG

1

60

Cervical LN

CT

DOD after 5 months

44

Defant, 2020

64

M

/

/

TaLG

/

0

Bone

ROM, CT, RT

NED after 11 years

45

Nishiyama, 2021

68

M

/

/

T1G2

0

51

Testis, para-aortic LN, peritoneum

ROM, CT

NED after 1.3 years

46

Xu, 2022

70

M

3

1

T1HG, ki67(65%+), p53(+), p63(+), EGFR(+), CD44(+)

0

41

Cervical LN

CT, ICI, RT

PR after 1.6 years