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Table 2 Univariate and multivariate analysis for disease-free survival and overall survival in HCC patients

From: Outcomes of adolescent and young patients with hepatocellular carcinoma after curative liver resection: a retrospective study

Characteristics Univariate analysis Multivariate analysis
Disease-free survival Overall survival Disease-free survival Overall survival
HR 95% CI
P value
HR 95% CI
P value
HR 95% CI
P value
HR 95% CI
P value
Age ≤ 40 2.2 1.2–2.8
< 0.01
2.1 1.4–2.6 < 0.01 1.8 1.1–3.1 < 0.01 2.3 1.3–3.2 < 0.01
AFP ≥ 100 ng/dL 1.2 1.1–2.1
< 0.05
1.6 1.2–2.4
< 0.05
   1.9 1.2–3.1
< 0.05
Sex male 0.3 NS 0.4 NS     
HBV-positive 0.5 NS 0.6 NS     
BMI ≥ 23 0.4 NS 0.3 NS     
Family history cancers 0.8 NS 0.7 NS     
Maximum tumor size > 5 cm 1.8 1.2–3.1
< 0.01
1.6 1.2–3.4
< 0.01
2.1 12–4.1
< 0.01
1.8 1.3–3.5
< 0.01
Multiple tumors 0.6 NS 0.4 NS     
Microvascular invasion 0.6 NS 0.8 NS     
Portal vein invasion 2.5 1.2–4.3
< 0.01
2.0 1.3–3.9
< 0.01
3.1 1.9–4.2
P < 0.01
2.2 1.3–3.4
P < 0.01
Satellite nodules 1.8 1.1–2.7
< 0.05
1.2 1.1–2.9
< 0.05
1.4 1.2–2.9
< 0.05
  
Edmondson grade 0.5 NS 0.3 NS     
Tumor capsule formation 0.4 0.1–08
< 0.05
0.6 0.2–0.9
< 0.05
0.5 0.1–0.8
< 0.05
0.7 0.1–0.9
< 0.05
Hepatic capsule invasion 0.3 NS 0.1 NS     
Microvascular tumor emboli 0.4 NS 0.2 NS     
TNM stage 3.1 1.8–4.9
< 0.01
2.2 1.5–3.6
< 0.01
3.0 1.3–4.3
< 0.01
2.1 1.5–3.9
< 0.01
Resection margin < 1 cm 0.7 NS 0.4 NS     
  1. NS not significant