Table 2 Univariate and multivariate analysis for disease-free survival and overall survival in HCC patients
Characteristics | Univariate analysis | Multivariate analysis | ||||||
|---|---|---|---|---|---|---|---|---|
Disease-free survival | Overall survival | Disease-free survival | Overall survival | |||||
HR | 95% CI P value | HR | 95% CI P value | HR | 95% CI P value | HR | 95% CI P value | |
Age ≤ 40 | 2.2 | 1.2–2.8 < 0.01 | 2.1 | 1.4–2.6 < 0.01 | 1.8 | 1.1–3.1 < 0.01 | 2.3 | 1.3–3.2 < 0.01 |
AFP ≥ 100 ng/dL | 1.2 | 1.1–2.1 < 0.05 | 1.6 | 1.2–2.4 < 0.05 | 1.9 | 1.2–3.1 < 0.05 | ||
Sex male | 0.3 | NS | 0.4 | NS | ||||
HBV-positive | 0.5 | NS | 0.6 | NS | ||||
BMI ≥ 23 | 0.4 | NS | 0.3 | NS | ||||
Family history cancers | 0.8 | NS | 0.7 | NS | ||||
Maximum tumor size > 5 cm | 1.8 | 1.2–3.1 < 0.01 | 1.6 | 1.2–3.4 < 0.01 | 2.1 | 12–4.1 < 0.01 | 1.8 | 1.3–3.5 < 0.01 |
Multiple tumors | 0.6 | NS | 0.4 | NS | ||||
Microvascular invasion | 0.6 | NS | 0.8 | NS | ||||
Portal vein invasion | 2.5 | 1.2–4.3 < 0.01 | 2.0 | 1.3–3.9 < 0.01 | 3.1 | 1.9–4.2 P < 0.01 | 2.2 | 1.3–3.4 P < 0.01 |
Satellite nodules | 1.8 | 1.1–2.7 < 0.05 | 1.2 | 1.1–2.9 < 0.05 | 1.4 | 1.2–2.9 < 0.05 | ||
Edmondson grade | 0.5 | NS | 0.3 | NS | ||||
Tumor capsule formation | 0.4 | 0.1–08 < 0.05 | 0.6 | 0.2–0.9 < 0.05 | 0.5 | 0.1–0.8 < 0.05 | 0.7 | 0.1–0.9 < 0.05 |
Hepatic capsule invasion | 0.3 | NS | 0.1 | NS | ||||
Microvascular tumor emboli | 0.4 | NS | 0.2 | NS | ||||
TNM stage | 3.1 | 1.8–4.9 < 0.01 | 2.2 | 1.5–3.6 < 0.01 | 3.0 | 1.3–4.3 < 0.01 | 2.1 | 1.5–3.9 < 0.01 |
Resection margin < 1 cm | 0.7 | NS | 0.4 | NS | ||||