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Table 1 Demographic, clinical, and laboratory data of breast cancer patients with IORT and non-IORT

From: The impact of intraoperative radiotherapy on breast cancer: focus on the levels of angiogenic factors

Variables

Non-IORT (n = 229)

IORT (n = 131)

p

Age

50 ± 63

51 ± 31

NS

Tumor side (%)

  

NS

Right

116 (78.5)

62 (47.3)

 

Left

113 (21.5)

69 (52.7)

 

Family history (%)

  

0.01

Negative

176 (76.8)

85 (65.5)

 

Positive

53 (23.2)

46 (34.5)

 

Histology (%)

  

NS

IDC

176 (76.8)

99 (75.5)

 

ILC

35 (15.3)

20 (15.3)

 

DCIS

14 (6.2)

11 (8.3)

 

Other types

4 (1.7)

1 (0.8)

 

ER (%)

  

0.01

Negative

86 (37.5)

33 (25.2)

 

Positive

143 (62.5)

98 (74.8)

 

PR (%)

  

NS

Negative

89 (38.9)

43 (32.8)

 

Positive

140 (61.1)

88 (67.2)

 

HER-2 (%)

  

NS

Negative

141 (67.3)

91 (71.7)

 

Positive

66 (32.7)

36 (28.3)

 

Tumor grade (%)

  

NS

I (well differentiation)

26 (11.4)

18 (13.7)

 

II (mod differentiation)

119 (51.9)

80 (61.1)

 

III (poor differentiation)

84 (36.7)

33 (25.2)

 

Vascular invasion (%)

  

NS

Negative

147 (64.2)

95 (72.5)

 

Positive

82 (35.8)

36 (27.5)

 

Perineural invasion (%)

  

NS

Negative

198 (86.5)

112 (85.5)

 

Positive

31 (13.5)

19 (14.5)

 

Calcification (%)

  

NS

Negative

185 (83.7)

114 (87.0)

 

Positive

36 (16.3)

17 (13.0)

 

Necrosis (%)

  

NS

Negative

170 (76.4)

95 (72.5)

 

Positive

51 (23.6)

36 (27.5)

 

Pathological T stage (%)

  

NS

T1 (≤ 2 cm)

100 (43.6)

64 (48.8)

 

T2 (> 2 cm, ≤ 5 cm)

120 (52.4)

67 (51.2)

 

T3 (> 5 cm)

9 (3.9)

0 (0)

 

Pathological N stage (%)

  

NS

N0

122 (53.3)

83 (63.4)

 

N1 (1–3)

59 (25.7)

29 (22.1)

 

N2 (4–9)

23 (10.1)

12 (9.2)

 

N3 ≥ 10

25 (10.9)

7 (5.3)

 

TNM stage (%)

  

NS

0

14 (6.1)

11 (8.5)

 

I

52 (22.7)

41 (31.8)

 

II

105 (45.8)

57 (44.2)

 

III

56 (24.4)

20 (15.5)

 

IV

2 (1.0)

0 (0)

 
  1. Values are presented as mean ± standard deviation or number (%). IORT intraoperative radiation therapy, DCIS ductal carcinoma in situ, IDC invasive ductal carcinoma, ILC invasive lobular carcinoma, ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor 2, TNM tumor, node, and metastasis