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Table 3 Univariate and multivariate (stepwise forward conditional method) Cox model regression for allograft bone union and revisions after 2 years of follow-up

From: Intercalary allograft reconstruction following femoral tumour resection: mid- and long-term results and benefits of adding a vascularised fibula autograft

 

Bone union, HRa (95.0% CI)

p-value

> 2 years revisions, HRa (95.0% CI)

p-value

Univariate analysis

 Gender (male)

1.06 (0.56–1.99)

0.860

1.29 (0.38–4.32)

0.672

 Age (years)b

0.99 (0.96–1.02)

0.460

1.01 (0.9–1.05)

0.790

 Resection length (mm)b

1.00 (0.94–1.06)

0.967

0.98 (0.87–1.10)

0.705

 Irradiated allograft

0.68 (0.35–1.32)

0.256

3.57 (1.12–11.48)

0.031

 Adjuvant radiotherapy

0.32 (0.09–1.05)

0.061

2.63 (0.72–9.71)

0.144

 Adjuvant chemotherapy

1.05 (0.51–2.14)

0.894

1.10 (0.33–4.55)

0.759

 Diagnosisc

  CHS (cref.)

 

0.841

 

0.661

  OS

0.75 (0.28–1.98)

0.556

0.48 (0.14–1.67)

0.251

  Ewing’s

0.84 (0.29–2.43)

0.742

1.20 (0.14–11.11)

0.866

 Associated graft

  VFG−: TG (cref.)

 

0.026

 

0.025

  CBG

1.98 (0.85–4.49)

0.112

0.25 (0.03–2.00)

0.192

  VFG+

2.64 (1.28–5.44)

0.008

0.17 (0.04–0.80)

0.024

 Stabilisation

  Nail (cref.)

 

0.149

 

0.095

  Plate

1.17 (0.54–2.51)

0.690

0.79 (0.13–4.98)

0.814

  Nail + plate

0.59 (0.27–1.30)

0.191

3.38 (0.83–12.82)

0.090

Multivariate analysis

Model p-value = 0.003

 

Model p-value = 0.010

 

Adjuvant RT

0.21 (0.06–0.74)

0.015

5.91 (1.19–29.38)

0.030

Irradiated allograft

  

6.00 (1.49–24.22)

0.012

Associated graft: VFG−: TG (cref.)

 

0.004

  

 CBG

1.89 (0.80–4.44)

0.145

  

 VFG+

3.81 (1.68–8.64)

0.001

  
  1. aHazard ratio. bContinuous variable. cReference variable in a categorical variable ≥ 3 levels