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Table 3 Univariable and multivariable analysis to identify predictors of overall survival of HCC patients after radical resection

From: Individual and joint influence of cytokeratin 19 and microvascular invasion on the prognosis of patients with hepatocellular carcinoma after hepatectomy

Variable Univariable Multivariable
HR 95% CI P HR 95% CI P
Lower Upper Lower Upper
Age (years) 0.993 0.974 1.012 0.449     
Sex (male/female) 0.716 0.399 1.286 0.264     
BCLC stage (0/A/B) 1.484 1.009 2.182 0.045     
HBsAg (negative/positive) 1.546 0.775 3.084 0.216     
HBV-DNA (< 5 × 102IU/ml/5 × 102IU/ml) 1.855 1.151 2.988 0.011 1.791 1.093 2.933 0.021
Anti-HCV (negative/positive) 0.455 0.063 3.284 0.435     
Tumor diameter (cm) 1.116 1.066 1.169 < 0.001 1.073 1.018 1.131 0.009
Tumor number (1/≥2) 1.415 0.913 2.193 0.121     
Tumor envelope (complete/incomplete) 2.281 1.459 3.569 < 0.001 2.169 1.368 3.440 0.001
Ascites (negative/positive) 1.862 1.055 3.286 0.032 1.659 0.922 2.985 0.091
AFP (<400 ng/ml/≥400 ng/ml) 1.237 0.824 1.857 0.305     
WBC (*109/L) 1.006 0.909 1.112 0.913     
N% (%) 1.018 0.998 1.039 0.082     
L% (%) 0.977 0.955 1.001 0.056     
HB (g/L) 0.998 0.987 1.010 0.771     
PLT (*109/L) 1.000 0.997 1.003 0.996     
FPG (mmol/L) 1.017 0.915 1.130 0.756     
PT (s) 1.041 0.876 1.237 0.651     
INR 1.658 0.310 8.872 0.554     
TBiL (μmol/L) 0.989 0.959 1.021 0.505     
Alb (g/L) 0.974 0.930 1.020 0.268     
PA (mg/L) 0.996 0.994 0.999 0.018 0.998 0.995 1.001 0.268
ALT (U/L) 0.997 0.989 1.004 0.396     
AST (U/L) 1.001 0.996 1.006 0.603     
GGT (U/L) 1.002 1.001 1.003 0.001 1.002 1.000 1.003 0.024
ALP (U/L) 1.006 1.003 1.008 < 0.001 1.004 1.001 1.008 0.026
CK19 (negative/positive) 1.641 1.060 2.540 0.026 1.471 0.936 2.313 0.094
MVI (negative/positive) 2.132 1.409 3.225 < 0.001 1.808 1.171 2.787 0.007
  1. Abbreviations: AFP alpha fetoprotein, Alb albumin, ALP alkaline phosphatase, ALT alanine aminotransferase, anti-HCV antibodies against hepatitis C virus, AST aspartate aminotransferase, BCLC Barcelona Clinic liver cancer, CK19 cytokeratin 19; FPG fasting plasma glucose, GGT γ-glutamyl transpeptidase, HB hemoglobin, HBsAg hepatitis B surface antigen, INR international normalized ratio, L% lymphocyte percentage, N% neutrophil percentage, MVI microvascular invasion, PA prealbumin, PLT blood platelets, PT prothrombin time, TBiL total bilirubin, WBC white blood cells