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Table 3 Univariable and multivariable analysis to identify predictors of overall survival of HCC patients after radical resection

From: Individual and joint influence of cytokeratin 19 and microvascular invasion on the prognosis of patients with hepatocellular carcinoma after hepatectomy

Variable

Univariable

Multivariable

HR

95% CI

P

HR

95% CI

P

Lower

Upper

Lower

Upper

Age (years)

0.993

0.974

1.012

0.449

    

Sex (male/female)

0.716

0.399

1.286

0.264

    

BCLC stage (0/A/B)

1.484

1.009

2.182

0.045

    

HBsAg (negative/positive)

1.546

0.775

3.084

0.216

    

HBV-DNA (< 5 × 102IU/ml/≧5 × 102IU/ml)

1.855

1.151

2.988

0.011

1.791

1.093

2.933

0.021

Anti-HCV (negative/positive)

0.455

0.063

3.284

0.435

    

Tumor diameter (cm)

1.116

1.066

1.169

< 0.001

1.073

1.018

1.131

0.009

Tumor number (1/≥2)

1.415

0.913

2.193

0.121

    

Tumor envelope (complete/incomplete)

2.281

1.459

3.569

< 0.001

2.169

1.368

3.440

0.001

Ascites (negative/positive)

1.862

1.055

3.286

0.032

1.659

0.922

2.985

0.091

AFP (<400 ng/ml/≥400 ng/ml)

1.237

0.824

1.857

0.305

    

WBC (*109/L)

1.006

0.909

1.112

0.913

    

N% (%)

1.018

0.998

1.039

0.082

    

L% (%)

0.977

0.955

1.001

0.056

    

HB (g/L)

0.998

0.987

1.010

0.771

    

PLT (*109/L)

1.000

0.997

1.003

0.996

    

FPG (mmol/L)

1.017

0.915

1.130

0.756

    

PT (s)

1.041

0.876

1.237

0.651

    

INR

1.658

0.310

8.872

0.554

    

TBiL (μmol/L)

0.989

0.959

1.021

0.505

    

Alb (g/L)

0.974

0.930

1.020

0.268

    

PA (mg/L)

0.996

0.994

0.999

0.018

0.998

0.995

1.001

0.268

ALT (U/L)

0.997

0.989

1.004

0.396

    

AST (U/L)

1.001

0.996

1.006

0.603

    

GGT (U/L)

1.002

1.001

1.003

0.001

1.002

1.000

1.003

0.024

ALP (U/L)

1.006

1.003

1.008

< 0.001

1.004

1.001

1.008

0.026

CK19 (negative/positive)

1.641

1.060

2.540

0.026

1.471

0.936

2.313

0.094

MVI (negative/positive)

2.132

1.409

3.225

< 0.001

1.808

1.171

2.787

0.007

  1. Abbreviations: AFP alpha fetoprotein, Alb albumin, ALP alkaline phosphatase, ALT alanine aminotransferase, anti-HCV antibodies against hepatitis C virus, AST aspartate aminotransferase, BCLC Barcelona Clinic liver cancer, CK19 cytokeratin 19; FPG fasting plasma glucose, GGT γ-glutamyl transpeptidase, HB hemoglobin, HBsAg hepatitis B surface antigen, INR international normalized ratio, L% lymphocyte percentage, N% neutrophil percentage, MVI microvascular invasion, PA prealbumin, PLT blood platelets, PT prothrombin time, TBiL total bilirubin, WBC white blood cells